Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Interferon Cytokine Res
2014 Oct 01;3410:795-801. doi: 10.1089/jir.2013.0137.
Show Gene links
Show Anatomy links
Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells.
Valle-Rios R
,
Maravillas-Montero JL
,
Burkhardt AM
,
Martinez C
,
Buhren BA
,
Homey B
,
Gerber PA
,
Robinson O
,
Hevezi P
,
Zlotnik A
.
???displayArticle.abstract???
Using a comprehensive microarray database of human gene expression, we identified that in mammals, a secreted protein known as isthmin 1 (ISM1) is expressed in skin, mucosal tissues, and selected lymphocyte populations. ISM1 was originally identified in Xenopus brain during development, and it encodes a predicted ∼50-kDa protein containing a signal peptide, a thrombospondin domain, and an adhesion-associated domain. We confirmed the pattern of expression of ISM1 in both human and mouse tissues. ISM1 is expressed by DX5(+) lung lymphocytes that include NK and NKT-like cells, and is also expressed by some CD4(+) T cells upon activation but its expression increases significantly when CD4(+) T cells were polarized to the Th17 lineage in vitro. The presence of IFN-γ during CD4(+) T cell polarization inhibits ISM1 expression. Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses.
Arase,
Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).
2001, Pubmed
Arase,
Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).
2001,
Pubmed
Basso,
More stories on Th17 cells.
2009,
Pubmed
Hevezi,
Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes.
2009,
Pubmed
Holt,
Regulation of immunological homeostasis in the respiratory tract.
2008,
Pubmed
Ivanov,
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
2006,
Pubmed
Kim,
Cancer immunoediting from immune surveillance to immune escape.
2007,
Pubmed
Lee,
Effects of RNA degradation on gene expression analysis of human postmortem tissues.
2005,
Pubmed
Li,
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.
2006,
Pubmed
Liu,
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.
2008,
Pubmed
Ortaldo,
The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells.
1998,
Pubmed
Pera,
Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.
2002,
Pubmed
,
Xenbase
Rossi,
TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.
2004,
Pubmed
Roth,
Gene expression analyses reveal molecular relationships among 20 regions of the human CNS.
2006,
Pubmed
Spits,
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.
2011,
Pubmed
Walzer,
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.
2007,
Pubmed
Weaver,
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective.
2009,
Pubmed
Werner,
DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice.
2011,
Pubmed
Wilke,
Th17 cells in cancer: help or hindrance?
2011,
Pubmed
Xiang,
Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.
2011,
Pubmed
,
Xenbase
Yu,
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.
2011,
Pubmed
Yuan,
Isthmin inhibits glioma growth through antiangiogenesis in vivo.
2012,
Pubmed
,
Xenbase
Zhang,
Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state.
2011,
Pubmed
Zhou,
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
2008,
Pubmed
Zhu,
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.
2010,
Pubmed
