Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Follicle Online: an integrated database of follicle assembly, development and ovulation.
Hua J
,
Xu B
,
Yang Y
,
Ban R
,
Iqbal F
,
Cooke HJ
,
Zhang Y
,
Shi Q
.
???displayArticle.abstract???
Folliculogenesis is an important part of ovarian function as it provides the oocytes for female reproductive life. Characterizing genes/proteins involved in folliculogenesis is fundamental for understanding the mechanisms associated with this biological function and to cure the diseases associated with folliculogenesis. A large number of genes/proteins associated with folliculogenesis have been identified from different species. However, no dedicated public resource is currently available for folliculogenesis-related genes/proteins that are validated by experiments. Here, we are reporting a database 'Follicle Online' that provides the experimentally validated gene/protein map of the folliculogenesis in a number of species. Follicle Online is a web-based database system for storing and retrieving folliculogenesis-related experimental data. It provides detailed information for 580 genes/proteins (from 23 model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Bos Taurus, Drosophila and Xenopus laevis) that have been reported to be involved in folliculogenesis, POF (premature ovarian failure) and PCOS (polycystic ovary syndrome). The literature was manually curated from more than 43,000 published articles (till 1 March 2014). The Follicle Online database is implemented in PHP + MySQL + JavaScript and this user-friendly web application provides access to the stored data. In summary, we have developed a centralized database that provides users with comprehensive information about genes/proteins involved in folliculogenesis. This database can be accessed freely and all the stored data can be viewed without any registration. Database URL: http://mcg.ustc.edu.cn/sdap1/follicle/index.php
Figure 2. (A) Screen shots of user interface—simple search. Simple search query using one of the six options provided e.g. Gene Name. (B) Screen shots of user interface—advance search. The search mode is an advanced search with multiple parameters that permits retrieval of very fine subsets of data.
Figure 3. Screen shots of user interface—result page. Collage of some of the results produced via clicking the ‘Browse’ button in both ‘Simple’ and ‘Advanced’ search options.
Figure 4. An example of potential protein network of folliculogenesis. The proteins in square frame (ESR1, PDK1, AKT1 and PTEN) are reported to participate in folliculogenesis. The proteins in circle are predicted to interact with the four proteins (in square boxes) either directly or indirectly. Red lines represents the experimentally verified interactions. Although the grey line shows the predicted interactions of proteins by our database.
Adhikari,
Molecular mechanisms underlying the activation of mammalian primordial follicles.
2009, Pubmed
Adhikari,
Molecular mechanisms underlying the activation of mammalian primordial follicles.
2009,
Pubmed
Assou,
The human cumulus--oocyte complex gene-expression profile.
2006,
Pubmed
BAKER,
A QUANTITATIVE AND CYTOLOGICAL STUDY OF GERM CELLS IN HUMAN OVARIES.
1963,
Pubmed
Broekmans,
Female reproductive ageing: current knowledge and future trends.
2007,
Pubmed
Brown,
Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.
2010,
Pubmed
Devoto,
The human corpus luteum: life cycle and function in natural cycles.
2009,
Pubmed
DiZerega,
Suppression of follicle-stimulating hormone-dependent folliculogenesis during the primate ovarian cycle.
1981,
Pubmed
Edson,
The mammalian ovary from genesis to revelation.
2009,
Pubmed
Edwards,
Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes.
1965,
Pubmed
Engelman,
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
2006,
Pubmed
Eppig,
Oocyte control of ovarian follicular development and function in mammals.
2001,
Pubmed
Faddy,
A model conforming the decline in follicle numbers to the age of menopause in women.
1996,
Pubmed
Fan,
MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.
2009,
Pubmed
Fathalla,
Incessant ovulation--a factor in ovarian neoplasia?
1971,
Pubmed
Goodarzi,
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis.
2011,
Pubmed
Hansen,
A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause.
2008,
Pubmed
Hirshfield,
Development of follicles in the mammalian ovary.
1991,
Pubmed
Jagarlamudi,
Genetically modified mouse models for premature ovarian failure (POF).
2010,
Pubmed
Jagarlamudi,
Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation.
2009,
Pubmed
John,
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.
2008,
Pubmed
Kerrien,
The IntAct molecular interaction database in 2012.
2012,
Pubmed
Kim,
Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure.
2011,
Pubmed
Leo,
The Ovarian Kaleidoscope database: an online resource for the ovarian research community.
2000,
Pubmed
Matzuk,
The biology of infertility: research advances and clinical challenges.
2008,
Pubmed
McGee,
Initial and cyclic recruitment of ovarian follicles.
2000,
Pubmed
Mehlmann,
Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation.
2005,
Pubmed
Pepling,
Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles.
2001,
Pubmed
Pepling,
From primordial germ cell to primordial follicle: mammalian female germ cell development.
2006,
Pubmed
Reddy,
PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
2009,
Pubmed
Richards,
Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation.
1980,
Pubmed
Richards,
Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization.
2002,
Pubmed
Rolaki,
Novel trends in follicular development, atresia and corpus luteum regression: a role for apoptosis.
2005,
Pubmed
Stark,
The BioGRID Interaction Database: 2011 update.
2011,
Pubmed
Vanderhyden,
Molecular basis of ovarian development and function.
2002,
Pubmed
Wandji,
Initiation in vitro of growth of bovine primordial follicles.
1996,
Pubmed
Welt,
Primary ovarian insufficiency: a more accurate term for premature ovarian failure.
2008,
Pubmed
Xenarios,
DIP: the database of interacting proteins.
2000,
Pubmed
Zanzoni,
MINT: a Molecular INTeraction database.
2002,
Pubmed
