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XB-ART-50847
Peptides 2016 Jun 01;80:4-8. doi: 10.1016/j.peptides.2015.05.015.
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Kbot55, purified from Buthus occitanus tunetanus venom, represents the first member of a novel α-KTx subfamily.

ElFessi-Magouri R , Peigneur S , Khamessi O , Srairi-Abid N , ElAyeb M , Mille BG , Cuypers E , Tytgat J , Kharrat R .


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Kbot55 is a 39 amino acid peptide isolated from the venom of the Tunisian scorpion Buthus occitanus tunetanus. This peptide is cross-linked by 3 disulfide bridges and has a molecular mass of 4128.65Da. Kbot55 is very low represented in the venom and thus represents a challenge for biochemical characterization. In this study, Kbot55 has been subjected to a screening on ion channels expressed in Xenopus laevis oocytes. It was found that Kbot55 targets voltage-gated potassium channels with high affinity. Kbot55 shows very low amino acid identity with other scorpion potassium toxins and therefore was considered a bona fide novel type of scorpion toxin. Sequence alignment analysis indicated that Kbot55 is the first representative of the new α-Ktx31 subfamily and therefore was classified as α-Ktx31.1.

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