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XB-ART-50911
Annu Rev Cell Dev Biol 2014 Jan 01;30:581-613. doi: 10.1146/annurev-cellbio-100913-013027.
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Zygotic genome activation during the maternal-to-zygotic transition.

Lee MT , Bonneau AR , Giraldez AJ .


Abstract
Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In animals, maternal factors contributed by the egg cytoplasm initially control development, whereas the zygotic nuclear genome is quiescent. Subsequently, the genome is activated, embryonic gene products are mobilized, and maternal factors are cleared. This transfer of developmental control is called the maternal-to-zygotic transition (MZT). In this review, we discuss recent advances toward understanding the scope, timing, and mechanisms that underlie zygotic genome activation at the MZT in animals. We describe high-throughput techniques to measure the embryonic transcriptome and explore how regulation of the cell cycle, chromatin, and transcription factors together elicits specific patterns of embryonic gene expression. Finally, we illustrate the interplay between zygotic transcription and maternal clearance and show how these two activities combine to reprogram two terminally differentiated gametes into a totipotent embryo.

PubMed ID: 25150012
PMC ID: PMC4303375
Article link: Annu Rev Cell Dev Biol
Grant support: [+]


References [+] :
Aanes, Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. 2011, Pubmed