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Targeted Inhibition of Snail Activity in Breast Cancer Cells by Using a Co(III) -Ebox Conjugate.
Vistain LF
,
Yamamoto N
,
Rathore R
,
Cha P
,
Meade TJ
.
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The transition from a non-invasive to an invasive phenotype is an essential step in tumor metastasis. The Snail family of transcription factors (TFs) is known to play a significant role in this transition. These TFs are zinc fingers that bind to the CAGGTG Ebox consensus sequence. Co(III) -Ebox is a cobalt(III) complex attached to an Ebox oligonucleotide that confers specificity towards Snail TFs. Co(III) -Ebox has been shown to inhibit Snail-mediated embryonic neural crest development in Xenopus laevis, but its efficacy in inhibiting Snail-induced cancer cell invasiveness has not been explored. Here, we describe the efficacy of Co(III) -Ebox in inhibiting the invasive aspects of heregulin-β1(HRG)-treated breast cancer cells. Co(III) -Ebox was found to inhibit the capacity of Snail to repress target genes after HRG induction. Snail inhibition by Co(III) -Ebox reduced the invasive propensity of cells in 2D and 3D, thereby demonstrating promise in inhibiting metastasis.
Adam,
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.
1998, Pubmed
Adam,
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.
1998,
Pubmed
Barrallo-Gimeno,
The Snail genes as inducers of cell movement and survival: implications in development and cancer.
2005,
Pubmed
Baum,
Transitions between epithelial and mesenchymal states in development and disease.
2008,
Pubmed
Brabletz,
To differentiate or not--routes towards metastasis.
2012,
Pubmed
Breuleux,
Role of heregulin in human cancer.
2007,
Pubmed
Cano,
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.
2000,
Pubmed
Cheng,
Heregulin-beta1 promotes metastasis of breast cancer cell line SKBR3 through upregulation of Snail and induction of epithelial-mesenchymal transition.
2009,
Pubmed
Coleman,
Metastasis and bone loss: advancing treatment and prevention.
2010,
Pubmed
De Craene,
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program.
2005,
Pubmed
Deryugina,
Matrix metalloproteinases and tumor metastasis.
2006,
Pubmed
Domínguez,
Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor.
2003,
Pubmed
Francí,
Expression of Snail protein in tumor-stroma interface.
2006,
Pubmed
Frixen,
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
1991,
Pubmed
Hajra,
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
2002,
Pubmed
Harney,
Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate.
2009,
Pubmed
,
Xenbase
Harney,
Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate.
2012,
Pubmed
,
Xenbase
Heffern,
Cobalt derivatives as promising therapeutic agents.
2013,
Pubmed
Heffern,
Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors by cobalt(III) Schiff base complexes.
2013,
Pubmed
Hurtado,
Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate.
2012,
Pubmed
Jordà,
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor.
2005,
Pubmed
Kim,
HRG-β1-driven ErbB3 signaling induces epithelial-mesenchymal transition in breast cancer cells.
2013,
Pubmed
Konstantinopoulos,
Seeing the future of cancer-associated transcription factor drug targets.
2011,
Pubmed
Kudo-Saito,
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
2009,
Pubmed
Louie,
A cobalt complex that selectively disrupts the structure and function of zinc fingers.
1998,
Pubmed
Manus,
Axial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics.
2013,
Pubmed
Maraveyas,
Malignant melanoma as a target malignancy for the study of the anti-metastatic properties of the heparins.
2010,
Pubmed
Mego,
Molecular mechanisms of metastasis in breast cancer--clinical applications.
2010,
Pubmed
Moody,
The transcriptional repressor Snail promotes mammary tumor recurrence.
2005,
Pubmed
Nieto,
The snail superfamily of zinc-finger transcription factors.
2002,
Pubmed
Pazos,
Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun.
2015,
Pubmed
Perl,
A causal role for E-cadherin in the transition from adenoma to carcinoma.
1998,
Pubmed
Portela,
ds-Oligonucleotide-peptide conjugates featuring peptides from the leucine-zipper region of Fos as switchable receptors for the oncoprotein Jun.
2007,
Pubmed
Robichaud,
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
2015,
Pubmed
Rodríguez-Martínez,
Small-molecule regulators that mimic transcription factors.
2010,
Pubmed
Ross,
The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.
1998,
Pubmed
Slamon,
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
1987,
Pubmed
Slamon,
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
1989,
Pubmed
Takeuchi,
Inhibition of thermolysin and human alpha-thrombin by cobalt(III) Schiff base complexes.
1999,
Pubmed
Thomas,
Non-viral gene therapy: polycation-mediated DNA delivery.
2003,
Pubmed
Vleminckx,
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
1991,
Pubmed
Voulgari,
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic.
2009,
Pubmed
Yang,
Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer.
2007,
Pubmed
Yao,
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
2001,
Pubmed
de Herreros,
Snail family regulation and epithelial mesenchymal transitions in breast cancer progression.
2010,
Pubmed
van Roy,
The cell-cell adhesion molecule E-cadherin.
2008,
Pubmed