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Sci Rep September 28, 2016; 6 22508.
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Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction.

De Jesús Andino F , Jones L , Maggirwar SB , Robert J .

While increasing evidence points to a key role of monocytes in amphibian host defenses, monocytes are also thought to be important in the dissemination and persistent infection caused by ranavirus. However, little is known about the fate of infected macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to establish a reservoir. The amphibian Xenopus laevis and Frog Virus 3 (FV3) were established as an experimental platform for investigating in vivo whether ranavirus could disseminate to the brain. Our data show that the FV3 infection alters the BBB integrity, possibly mediated by an inflammatory response, which leads to viral dissemination into the central nervous system in X. laevis tadpole but not adult. Furthermore, our data suggest that the macrophages play a major role in viral dissemination by carrying the virus into the neural tissues.

PubMed ID: 26931458
PMC ID: PMC4773881
Article link: Sci Rep
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: mhc2-dma (provisional) otc tnf
Antibodies: Macrophage Ab1 Mhc2a Ab1

Article Images: [+] show captions
References [+] :
Birngruber, Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier. 2013, Pubmed