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Development April 15, 2017; 144 (8): 1477-1483.
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Stomach curvature is generated by left-right asymmetric gut morphogenesis.

Davis A , Amin NM , Johnson C , Bagley K , Ghashghaei HT , Nascone-Yoder N .

Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here, we show in mouse and Xenopus that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement. These asymmetries exist across several species, and are dependent on LR patterning genes, including Foxj1, Nodal and Pitx2 Our findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts.

PubMed ID: 28242610
PMC ID: PMC5399665
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cdh1 ctnnb1 foxj1.2 itgb1 nodal nodal1 pard3 pitx2 prkci prkcz tub tuba4b tubg1
GO keywords: foregut morphogenesis [+]
Antibodies: Cdh1 Ab1 Ctnnb1 Ab2 Itgb1 Ab1 Pard3 Ab1 Prkcz Ab1 Tuba4b Ab2 Tubg1 Ab6
Morpholinos: pitx2 MO2 pitx2 MO3
gRNAs referenced: pitx2 gRNA1

Phenotypes: Xla Wt + SB505124 (Fig. 2. LP) [+]

Article Images: [+] show captions
References [+] :
Al Alam, FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. 2012, Pubmed