Sharma M , Castro-Piedras I , Simmons GE , Pruitt K .

R01 CA155223 NCI NIH HHS

Anastas, WNT signalling pathways as therapeutic targets in cancer. 2013, Pubmed

Anastas, WNT signalling pathways as therapeutic targets in cancer. 2013, Pubmed
Andersson, CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. 2009, Pubmed
Angers, The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. 2006, Pubmed , Xenbase
Axelrod, Interaction between Wingless and Notch signaling pathways mediated by dishevelled. 1996, Pubmed
Ayyanan, Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. 2006, Pubmed
Badders, The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. 2009, Pubmed
Benjamin, mRNA stability and cancer: an emerging link? 2007, Pubmed
Bernatik, Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. 2011, Pubmed
Bernatík, Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5. 2014, Pubmed , Xenbase
Berthold, Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism. 2008, Pubmed
Björklund, The internally truncated LRP5 receptor presents a therapeutic target in breast cancer. 2009, Pubmed
Bocchinfuso, A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. 1999, Pubmed
Boutros, Dishevelled: at the crossroads of divergent intracellular signaling pathways. 1999, Pubmed , Xenbase
Brown, A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. 1986, Pubmed
Bryja, Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. 2007, Pubmed , Xenbase
Bunn, Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome. 2015, Pubmed
Capelluto, Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain. 2005, Pubmed
Capelluto, The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. 2002, Pubmed , Xenbase
Cervenka, Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins. 2016, Pubmed
Chan, Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. 2006, Pubmed
Chen, Expression of dishevelled gene in Hirschsprung's disease. 2013, Pubmed
Chen, Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 2003, Pubmed
Chen, beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 2001, Pubmed
Cheyette, Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. 2002, Pubmed , Xenbase
Cong, Casein kinase Iepsilon modulates the signaling specificities of dishevelled. 2004, Pubmed
Dass, Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. 2016, Pubmed
Deitrick, Wnt/β Catenin-Mediated Signaling Commonly Altered in Colorectal Cancer. 2016, Pubmed
Deng, Dishevelled interacts with p65 and acts as a repressor of NF-κB-mediated transcription. 2010, Pubmed
DiMeo, A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. 2009, Pubmed
Ding, HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation. 2013, Pubmed , Xenbase
Dollar, Regulation of Lethal giant larvae by Dishevelled. 2005, Pubmed , Xenbase
Egger-Adam, The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway. 2010, Pubmed
Ehebauer, The structural and functional determinants of the Axin and Dishevelled DIX domains. 2009, Pubmed
Elbert, PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. 2006, Pubmed
Etheridge, Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. 2008, Pubmed
FAHMY, Complementation among the subgenic mutants in the r-locus of Drosophila melangogaster. 1959, Pubmed
Fahmy, Differential Gene Response to Mutagens in Drosophila Melanogaster. 1959, Pubmed
Ford, Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. 2009, Pubmed
Fujii, An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. 2007, Pubmed
Gammons, Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. 2016, Pubmed
Gan, Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. 2008, Pubmed
Gao, Dishevelled: The hub of Wnt signaling. 2010, Pubmed
Gavin, Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. 1992, Pubmed
Gloy, Frodo interacts with Dishevelled to transduce Wnt signals. 2002, Pubmed , Xenbase
Goold, Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones. 1999, Pubmed
Goto, IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. 2013, Pubmed , Xenbase
Grandy, Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. 2009, Pubmed , Xenbase
Griseri, Regulation of the mRNA half-life in breast cancer. 2014, Pubmed
Habas, Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. 2001, Pubmed , Xenbase
Habas, Dishevelled and Wnt signaling: is the nucleus the final frontier? 2005, Pubmed
Habas, Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. 2003, Pubmed , Xenbase
Hall, Role of Wnts in prostate cancer bone metastases. 2006, Pubmed
Hamblet, Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. 2002, Pubmed
Hino, Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. 2001, Pubmed , Xenbase
Holloway, SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. 2010, Pubmed
Howe, Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. 2003, Pubmed
Hsieh, A new secreted protein that binds to Wnt proteins and inhibits their activities. 1999, Pubmed , Xenbase
Huang, Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. 2013, Pubmed , Xenbase
Huguet, Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. 1994, Pubmed
Hussain, Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. 2009, Pubmed
Itoh, Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. 2005, Pubmed , Xenbase
Jenny, Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. 2005, Pubmed
Jung, Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. 2009, Pubmed , Xenbase
Kafka, Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin. 2014, Pubmed
Kfir-Erenfeld, miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. 2017, Pubmed
Khan, Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia. 2016, Pubmed
Kim, CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. 2015, Pubmed
Kinoshita, PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. 2003, Pubmed , Xenbase
Kishida, DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. 1999, Pubmed
Klarmann, Epigenetic gene silencing in the Wnt pathway in breast cancer. 2008, Pubmed
Klein, Planar cell polarization: an emerging model points in the right direction. 2005, Pubmed
Klimowski, Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. 2006, Pubmed , Xenbase
Klingensmith, Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 1996, Pubmed , Xenbase
Korinek, Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. 1997, Pubmed
Kossatz, The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. 2010, Pubmed
Krausova, Wnt signaling in adult intestinal stem cells and cancer. 2014, Pubmed
Le Garrec, Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways. 2008, Pubmed
Lee, Fibroblast growth factor receptor-induced phosphorylation of ephrinB1 modulates its interaction with Dishevelled. 2009, Pubmed , Xenbase
Lee, Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. 2010, Pubmed , Xenbase
Lee, PDZ domains and their binding partners: structure, specificity, and modification. 2010, Pubmed
Lee, Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5. 2017, Pubmed
Lee, The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. 2015, Pubmed
Lee, Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway. 2006, Pubmed , Xenbase
Lee, Cullins and cancer. 2010, Pubmed
Lee, Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. 2008, Pubmed
Li, Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. 1999, Pubmed , Xenbase
Li, Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. 2003, Pubmed
Li, The expression and significance of dishevelled in human glioma. 2014, Pubmed
Lijam, Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. 1997, Pubmed
Liu, LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. 2010, Pubmed
Liu, Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway. 2017, Pubmed
Liu, The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. 2004, Pubmed
Lo, Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. 2006, Pubmed
Logan, The Wnt signaling pathway in development and disease. 2004, Pubmed
Louie, Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. 2009, Pubmed , Xenbase
Lu, Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. 2004, Pubmed
Lucas, Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. 1998, Pubmed
MacDonald, Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. 2012, Pubmed
Mahindroo, Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. 2008, Pubmed
Mahipal, Importins and exportins as therapeutic targets in cancer. 2016, Pubmed
Matsumoto, Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. 2010, Pubmed
Miyakoshi, Rho guanine nucleotide exchange factor xNET1 implicated in gastrulation movements during Xenopus development. 2004, Pubmed , Xenbase
Mlodzik, The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies. 2016, Pubmed
Moeller, Diversin regulates heart formation and gastrulation movements in development. 2006, Pubmed
Momose, A conserved function for Strabismus in establishing planar cell polarity in the ciliated ectoderm during cnidarian larval development. 2012, Pubmed
Moon, WNT and beta-catenin signalling: diseases and therapies. 2004, Pubmed
Moon, Developmental biology: signalling polarity. 2002, Pubmed , Xenbase
Morin, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. 1997, Pubmed
Nagahata, Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. 2003, Pubmed
Nusse, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. 1982, Pubmed
Nusse, Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. , Pubmed
Ossipova, Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. 2005, Pubmed , Xenbase
Pan, Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. 2004, Pubmed
Park, The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. 2002, Pubmed , Xenbase
Park, Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos. 2005, Pubmed , Xenbase
Perrimon, Multiple functions of segment polarity genes in Drosophila. 1987, Pubmed
Person, WNT5A mutations in patients with autosomal dominant Robinow syndrome. 2010, Pubmed , Xenbase
Peters, Casein kinase I transduces Wnt signals. 1999, Pubmed , Xenbase
Pizzuti, Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. 1996, Pubmed , Xenbase
Pizzuti, cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. 1996, Pubmed
Prasad, Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expression. 2007, Pubmed
Pruitt, Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. 2006, Pubmed
Rousset, Naked cuticle targets dishevelled to antagonize Wnt signal transduction. 2001, Pubmed
Sakanaka, Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. 1998, Pubmed
Sakanaka, Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. 1999, Pubmed , Xenbase
Saxena, The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. 2015, Pubmed
Schwarz-Romond, Dynamic recruitment of axin by Dishevelled protein assemblies. 2007, Pubmed
Schwarz-Romond, The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. 2007, Pubmed
Semënov, Human dishevelled genes constitute a DHR-containing multigene family. 1997, Pubmed
Shackleton, Generation of a functional mammary gland from a single stem cell. 2006, Pubmed
Sheldahl, Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. 2003, Pubmed , Xenbase
Shiomi, Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. 2003, Pubmed
Simmons, Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells. 2014, Pubmed
Slusarski, Calcium signaling in vertebrate embryonic patterning and morphogenesis. 2007, Pubmed
Sokol, Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 1995, Pubmed , Xenbase
Song, Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. 2000, Pubmed
Stingl, Purification and unique properties of mammary epithelial stem cells. 2006, Pubmed
Strovel, Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. 2000, Pubmed
Strutt, Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye. 2002, Pubmed
Stubbins, Using components of the vitamin D pathway to prevent and treat colon cancer. 2012, Pubmed
Sun, PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. 2001, Pubmed , Xenbase
Sussman, Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. 1994, Pubmed
Suzuki, Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. 2008, Pubmed
Taipale, The Hedgehog and Wnt signalling pathways in cancer. 2001, Pubmed
Tanaka, Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. 2003, Pubmed , Xenbase
Tanegashima, WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. 2008, Pubmed , Xenbase
Tauriello, Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. 2010, Pubmed
Tran, Modulating the wnt signaling pathway with small molecules. 2017, Pubmed
Tree, Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. 2002, Pubmed
Tsang, Isolation and characterization of mouse dishevelled-3. 1996, Pubmed
Veeck, Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. 2006, Pubmed
Veeck, Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. 2008, Pubmed
Veeman, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. 2003, Pubmed
Velázquez, Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists. 2017, Pubmed
Wallingford, The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. 2005, Pubmed
Wallingford, Convergent extension: the molecular control of polarized cell movement during embryonic development. 2002, Pubmed , Xenbase
Wang, FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. 2015, Pubmed
Wang, Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. 2015, Pubmed
Wei, Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. 2008, Pubmed
Wei, The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. 2012, Pubmed
Weitzman, Dishevelled nuclear shuttling. 2005, Pubmed
Weston, Signal transduction: signaling specificity- a complex affair. 2001, Pubmed
Wharton, Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. 2003, Pubmed
Wharton, Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. 2001, Pubmed
White, DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome. 2015, Pubmed
White, DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome. 2016, Pubmed
Willert, Casein kinase 2 associates with and phosphorylates dishevelled. 1997, Pubmed
Witte, Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. 2010, Pubmed , Xenbase
Wong, Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. 2003, Pubmed , Xenbase
Wong, Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. 2000, Pubmed
Wu, Delicate analysis of post-translational modifications on Dishevelled 3. 2012, Pubmed
Yanagawa, The dishevelled protein is modified by wingless signaling in Drosophila. 1995, Pubmed
Yang, Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. 2004, Pubmed
Yuan, Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. 2017, Pubmed
Zaveri, Identification of critical regions and candidate genes for cardiovascular malformations and cardiomyopathy associated with deletions of chromosome 1p36. 2014, Pubmed
Zhang, Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. 2016, Pubmed
Zhang, Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. 2006, Pubmed , Xenbase
Zhang, Overexpression of dishevelled 2 is involved in tumor metastasis and is associated with poor prognosis in hepatocellular carcinoma. 2017, Pubmed
Zhang, Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis. 2017, Pubmed
Zhang, Inhibition of Wnt signaling by Dishevelled PDZ peptides. 2009, Pubmed
Zhang, Dishevelled promotes axon differentiation by regulating atypical protein kinase C. 2007, Pubmed
Zhao, Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer. 2014, Pubmed , Xenbase
Zhou, The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation. 2014, Pubmed
van Amerongen, Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways. 2010, Pubmed
van Gijn, The wnt-frizzled cascade in cardiovascular disease. 2002, Pubmed
Čajánek, Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. 2013, Pubmed