Janmey PA , Bucki R , Radhakrishnan R .

R01 GM083272 NIGMS NIH HHS , R01 GM111942 NIGMS NIH HHS

Al-Momany, Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A. 2014, Pubmed

Al-Momany, Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A. 2014, Pubmed
Ben-Salem, Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy. 2018, Pubmed
Benesch, Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. 2002, Pubmed
Bittner, Phosphatidylinositol-4,5-bisphosphate: actin dynamics and the regulation of ATP-dependent and -independent secretion. 2005, Pubmed
Bosk, Activation of F-actin binding capacity of ezrin: synergism of PIP₂ interaction and phosphorylation. 2011, Pubmed
Bradley, Curvature-undulation coupling as a basis for curvature sensing and generation in bilayer membranes. 2016, Pubmed
Bucki, Phosphatidylinositol 4,5-bisphosphate domain inducers promote phospholipid transverse redistribution in biological membranes. 2000, Pubmed
Bucki, Calcium induces phospholipid redistribution and microvesicle release in human erythrocyte membranes by independent pathways. 1998, Pubmed
Bunney, Phosphoinositide signalling in cancer: beyond PI3K and PTEN. 2010, Pubmed
Burda, Manipulation of the Host Cell Membrane during Plasmodium Liver Stage Egress. 2017, Pubmed
Catimel, The PI(3,5)P2 and PI(4,5)P2 interactomes. 2008, Pubmed
Chen, Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering. 2015, Pubmed
Chinthalapudi, Lipid binding promotes oligomerization and focal adhesion activity of vinculin. 2014, Pubmed
Chinthalapudi, Lipid-directed vinculin dimerization. 2015, Pubmed
Corgan, Phosphoinositides differentially regulate alpha-actinin flexibility and function. 2004, Pubmed
Cunningham, Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. 2001, Pubmed
Daste, Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature. 2017, Pubmed , Xenbase
Diz-Muñoz, Use the force: membrane tension as an organizer of cell shape and motility. 2013, Pubmed
Dwivedi, Binding of Vinculin to Lipid Membranes in Its Inhibited and Activated States. 2016, Pubmed
Elliott, The Structure of the talin head reveals a novel extended conformation of the FERM domain. 2010, Pubmed
Fukami, alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. 1994, Pubmed
Fukami, Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. 1992, Pubmed
Fukami, Identification of a phosphatidylinositol 4,5-bisphosphate-binding site in chicken skeletal muscle alpha-actinin. 1996, Pubmed
Funakoshi, Regulation of PIP5K activity by Arf6 and its physiological significance. 2011, Pubmed
Furuhashi, Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin. 1992, Pubmed
Gallop, Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. 2013, Pubmed , Xenbase
Golebiewska, Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells. 2008, Pubmed
Gorbatyuk, Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. 2006, Pubmed
Gorelik, Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. 2011, Pubmed
Herrig, Cooperative adsorption of ezrin on PIP2-containing membranes. 2006, Pubmed
Higgs, Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. 2000, Pubmed
Hou, n-3 polyunsaturated fatty acids suppress CD4(+) T cell proliferation by altering phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] organization. 2016, Pubmed
Hübner, Enhancement of phosphoinositide 3-kinase (PI 3-kinase) activity by membrane curvature and inositol-phospholipid-binding peptides. 1998, Pubmed
Janmey, Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. 1992, Pubmed
Janmey, Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. , Pubmed
Kallikourdis, Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse. 2016, Pubmed
Kapus, Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations. 2013, Pubmed
Kawamura, N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. 2004, Pubmed
Khuong, WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. 2010, Pubmed
Koldsø, Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers. 2014, Pubmed
Kooijman, Ionization properties of phosphatidylinositol polyphosphates in mixed model membranes. 2009, Pubmed
Kozlov, Processive capping by formin suggests a force-driven mechanism of actin polymerization. 2004, Pubmed
Kwiatkowska, One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane. 2010, Pubmed
Lassing, Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. , Pubmed
Lassing, Specificity of the interaction between phosphatidylinositol 4,5-bisphosphate and the profilin:actin complex. 1988, Pubmed
Le, Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase γ by Akt regulates its interaction with talin and focal adhesion dynamics. 2015, Pubmed
Levental, Combined electrostatics and hydrogen bonding determine intermolecular interactions between polyphosphoinositides. 2008, Pubmed
Levental, Electrostatic contribution to the surface pressure of charged monolayers containing polyphosphoinositides. 2008, Pubmed
Ma, Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. 1998, Pubmed , Xenbase
Mao, Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. 2007, Pubmed
Miki, N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. 1996, Pubmed
Miled, Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. 2007, Pubmed
Mondal, Optically sensing phospholipid induced coil-helix transitions in the phosphoinositide-binding motif of gelsolin. 2018, Pubmed
Moravcevic, Conditional peripheral membrane proteins: facing up to limited specificity. 2012, Pubmed
Naughton, Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition. 2018, Pubmed
Niggli, Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin. 1995, Pubmed
Pogoda, Soft Substrates Containing Hyaluronan Mimic the Effects of Increased Stiffness on Morphology, Motility, and Proliferation of Glioma Cells. 2017, Pubmed
Ramakrishnan, Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales. 2018, Pubmed
Ramalingam, Phospholipids regulate localization and activity of mDia1 formin. 2010, Pubmed
Rohatgi, Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. 2000, Pubmed , Xenbase
Rohatgi, Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. 2001, Pubmed
Rouven Brückner, Ezrin is a Major Regulator of Membrane Tension in Epithelial Cells. 2015, Pubmed
Rozelle, Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. 2000, Pubmed
Rubashkin, Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. 2014, Pubmed
Sakisaka, Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. 1997, Pubmed
Sen, Contributions of talin-1 to glioma cell-matrix tensional homeostasis. 2012, Pubmed
Sengelaub, PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling. 2016, Pubmed
Senju, Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides. 2017, Pubmed
Shabardina, Mode of Ezrin-Membrane Interaction as a Function of PIP2 Binding and Pseudophosphorylation. 2016, Pubmed
Shibasaki, Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. 1997, Pubmed
Sohn, Localization of a binding site for phosphatidylinositol 4,5-bisphosphate on human profilin. 1995, Pubmed
Song, A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. 2012, Pubmed
Sun, Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer. 2010, Pubmed
Sun, Molecular Dynamics of the Association of L-Selectin and FERM Regulated by PIP2. 2018, Pubmed
Tsujita, Phosphoinositides in the regulation of actin cortex and cell migration. 2015, Pubmed
Tsujita, Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. 2010, Pubmed
Walrant, Triggering actin polymerization in Xenopus egg extracts from phosphoinositide-containing lipid bilayers. 2015, Pubmed , Xenbase
Wang, Counterion-mediated cluster formation by polyphosphoinositides. 2014, Pubmed
Wang, Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. 2012, Pubmed
Yamamoto, Computational and theoretical approaches for studies of a lipid recognition protein on biological membranes. 2017, Pubmed
Yamamoto, Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. 2001, Pubmed
Ye, Conformational equilibrium of talin is regulated by anionic lipids. 2016, Pubmed
Yin, Phosphoinositide regulation of the actin cytoskeleton. 2003, Pubmed
van Gisbergen, Class II formin targeting to the cell cortex by binding PI(3,5)P(2) is essential for polarized growth. 2012, Pubmed
van den Bout, PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. 2009, Pubmed