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XB-ART-56005
Bioorg Med Chem Lett 2019 Aug 01;2915:1928-1933. doi: 10.1016/j.bmcl.2019.05.046.
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Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs.

Li X , Xie W , Wang X , Huang Z , Bian X , Wang K , Sun Q .


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Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human α7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 ± 1.13 μM and the maximum activation effect of α7 current over 1474 ± 246% in the presence of acetylcholine (100 μM). It is highly specific to α7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of α7 nAChR may be beneficial for improvement of cognitive deficit.

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Species referenced: Xenopus
Genes referenced: pam