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Dev Cell February 1, 2009; 16 (2): 165-6.
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SUMO weighs in on a photoreceptor finish.

In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.

PubMed ID: 19217419
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: nr2e3 pias3