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Int J Mol Sci March 28, 2020; 21 (7):
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Understanding MAPK Signaling Pathways in Apoptosis.

Yue J , López JM .

MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. In this review, we present the main pro- and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs'' behavior, based on the intensity and duration of the stimulus. Finally, we consider the role of MAPKs in osmostress-induced apoptosis by using Xenopus oocytes as a cell model. As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will help to understand how MAPK signaling pathways engage irreversible cellular decisions.

PubMed ID: 32231094
PMC ID: PMC7177758
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Xenopus
Genes referenced: bax bcl2l11 bid bmf daxx fh itch jun map3k1 mapk1 mapk14 mapk8 tp53
GO keywords: MAPK cascade [+]

Article Images: [+] show captions
References [+] :
Abrieu, The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. 1999, Pubmed, Xenbase