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XB-ART-56905
Dev Biol August 1, 2020; 464 (1): 71-87.
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Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.

Vonica A , Bhat N , Phan K , Guo J , Iancu L , Weber JA , Karger A , Cain JW , Wang ECE , DeStefano GM , O'Donnell-Luria AH , Christiano AM , Riley B , Butler SJ , Luria V .


Abstract
Animal development and homeostasis depend on precise temporal and spatial intercellular signaling. Components shared between signaling pathways, generally thought to decrease specificity, paradoxically can also provide a solution to pathway coordination. Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. Previously, we showed that Apcdd1 inhibits Wnt signaling (Shimomura et al., 2010), here we find that Apcdd1 potently inhibits BMP signaling in body axis formation and neural differentiation in chicken, frog, zebrafish. Furthermore, we find that Apcdd1 has an evolutionarily novel protein domain. Our results from experiments and modeling suggest that Apcdd1 may coordinate the outputs of two signaling pathways that are central to animal development and human disease.

PubMed ID: 32320685
PMC ID: PMC7307705
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acvr1b apcdd1 babam2 bmp2 bmp7.1 bmpr2 chrd.1 gsc nodal sox2 szl
GO keywords: embryo development [+]
Morpholinos: admp MO1 bmp2 MO1 bmp4 MO1 bmp7.2 MO1


Article Images: [+] show captions
References [+] :
Abrusán, Integration of new genes into cellular networks, and their structural maturation. 2014, Pubmed