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Front Cell Dev Biol July 14, 2020; 8 586158.
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MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs.

Alwin Prem Anand A , Alvarez-Bolado G , Wizenmann A .

MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function.

PubMed ID: 33330463
Article link: Front Cell Dev Biol

Genes referenced: en1 fgf8 gbx2.1 gnao1 hes5.2 notch1 otx2 pax2 wnt1 zic1
GO keywords: brain development [+]

Disease Ontology terms: Rett syndrome [+]

Article Images: [+] show captions
References [+] :
Alvarado-Mallart, Pluripotentiality of the 2-day-old avian germinative neuroepithelium. 1990, Pubmed