Liu Y , Xu X , Gao J , Naffaa MM , Liang H , Shi J , Wang HZ , Yang ND , Hou P , Zhao W , White KM , Kong W , Dou A , Cui A , Zhang G , Cohen IS , Zou X , Cui J .

R01 GM109980 NIGMS NIH HHS , R01 HL126774 NHLBI NIH HHS , R35 GM136409 NIGMS NIH HHS , HL126774 NHLBI NIH HHS , 18POST34030203 American Heart Association-American Stroke Association

Barhanin, K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. 1996, Pubmed, Xenbase

Barhanin, K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. 1996, Pubmed , Xenbase
Barro-Soria, KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps. 2014, Pubmed
Barsheshet, Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome. 2012, Pubmed
Bian, HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. 2001, Pubmed
Brown, Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. 1980, Pubmed
Chen, KCNQ1 gain-of-function mutation in familial atrial fibrillation. 2003, Pubmed
Choveau, Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains. 2018, Pubmed
Chowdhury, Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels. 2012, Pubmed
Delmas, Pathways modulating neural KCNQ/M (Kv7) potassium channels. 2005, Pubmed
Gao, Isoprenaline, Ca2+ and the Na(+)-K+ pump in guinea-pig ventricular myocytes. 1992, Pubmed
Gómez-Posada, A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression. 2010, Pubmed , Xenbase
Hedley, The genetic basis of long QT and short QT syndromes: a mutation update. 2009, Pubmed
Hernandez, Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels. 2009, Pubmed
Hou, Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening. 2017, Pubmed , Xenbase
Hou, Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation. 2020, Pubmed
Hou, ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. 2019, Pubmed , Xenbase
Huang, An iterative knowledge-based scoring function to predict protein-ligand interactions: II. Validation of the scoring function. 2006, Pubmed
Huang, An iterative knowledge-based scoring function to predict protein-ligand interactions: I. Derivation of interaction potentials. 2006, Pubmed
Huang, Efficient molecular docking of NMR structures: application to HIV-1 protease. 2007, Pubmed
Huang, Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. 1998, Pubmed , Xenbase
Jost, Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. 2005, Pubmed
Kasimova, PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6. 2015, Pubmed
Kim, PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels. 2017, Pubmed , Xenbase
King, Kv7.5 is the primary Kv7 subunit expressed in C-fibers. 2012, Pubmed
Kubisch, KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. 1999, Pubmed , Xenbase
Lerche, Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. 2000, Pubmed , Xenbase
Li, Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. 2005, Pubmed
Li, KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity. 2011, Pubmed , Xenbase
Liin, Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1. 2018, Pubmed , Xenbase
Long, Voltage sensor of Kv1.2: structural basis of electromechanical coupling. 2005, Pubmed
Long, Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. 2007, Pubmed
Loussouarn, Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels. 2003, Pubmed
Lu, Coupling between voltage sensors and activation gate in voltage-gated K+ channels. 2002, Pubmed , Xenbase
Ma, Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis. 2011, Pubmed , Xenbase
Matavel, PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions. 2010, Pubmed , Xenbase
Murata, Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. 2005, Pubmed , Xenbase
Nakajo, Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes. 2005, Pubmed , Xenbase
Nerbonne, Molecular physiology of cardiac repolarization. 2005, Pubmed
Neyroud, A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. 1997, Pubmed
Osteen, KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate. 2010, Pubmed , Xenbase
Pettersen, UCSF Chimera--a visualization system for exploratory research and analysis. 2004, Pubmed
Pian, Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. 2006, Pubmed , Xenbase
Roche, Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels. 2002, Pubmed
Sanguinetti, Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. 1996, Pubmed , Xenbase
Schmidt, Phospholipids and the origin of cationic gating charges in voltage sensors. 2006, Pubmed
Selyanko, Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. 2000, Pubmed
Shapiro, Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. 2000, Pubmed
Suh, Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. 2002, Pubmed
Suh, Regulation of KCNQ channels by manipulation of phosphoinositides. 2007, Pubmed
Suh, Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. 2010, Pubmed
Suh, Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. 2006, Pubmed
Sun, Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. 2017, Pubmed , Xenbase
Sun, Structural Basis of Human KCNQ1 Modulation and Gating. 2020, Pubmed
Telezhkin, A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂. 2013, Pubmed
Telezhkin, Distinct subunit contributions to the activation of M-type potassium channels by PI(4,5)P2. 2012, Pubmed
Telezhkin, Structural requirements of membrane phospholipids for M-type potassium channel activation and binding. 2012, Pubmed
Thomas, Characterization of a binding site for anionic phospholipids on KCNQ1. 2011, Pubmed
Tian, Large-conductance Ca2+- and voltage-gated K+ channels form and break interactions with membrane lipids during each gating cycle. 2019, Pubmed
Tian, Atomic determinants of BK channel activation by polyunsaturated fatty acids. 2016, Pubmed
Tobelaim, Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels. 2017, Pubmed
Vainio, ShaEP: molecular overlay based on shape and electrostatic potential. 2009, Pubmed
Wang, Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. 1996, Pubmed
Wang, KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. 1998, Pubmed , Xenbase
Wu, State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation. 2010, Pubmed , Xenbase
Wu, KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function. 2010, Pubmed , Xenbase
Xu, Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels. 2008, Pubmed , Xenbase
Xu, Predicting protein-ligand binding modes for CELPP and GC3: workflows and insight. 2019, Pubmed
Yan, Iterative Knowledge-Based Scoring Functions Derived from Rigid and Flexible Decoy Structures: Evaluation with the 2013 and 2014 CSAR Benchmarks. 2016, Pubmed
Zaydman, Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. 2013, Pubmed , Xenbase
Zaydman, Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel. 2014, Pubmed , Xenbase
Zhang, PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. 2003, Pubmed , Xenbase
Zhang, Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. 2013, Pubmed , Xenbase
Zhang, Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels. 2017, Pubmed , Xenbase
Zheng, Lipid-dependent gating of a voltage-gated potassium channel. 2011, Pubmed