XB-ART-58246
Biology (Basel)
2021 Jun 09;106:. doi: 10.3390/biology10060513.
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Temporal Gradients Controlling Embryonic Cell Cycle.
Liu B
,
Zhao H
,
Wu K
,
Großhans J
.
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Cell proliferation in early embryos by rapid cell cycles and its abrupt pause after a stereotypic number of divisions present an attractive system to study the timing mechanism in general and its coordination with developmental progression. In animals with large eggs, such as Xenopus, zebrafish, or Drosophila, 11-13 very fast and synchronous cycles are followed by a pause or slowdown of the cell cycle. The stage when the cell cycle is remodeled falls together with changes in cell behavior and activation of the zygotic genome and is often referred to as mid-blastula transition. The number of fast embryonic cell cycles represents a clear and binary readout of timing. Several factors controlling the cell cycle undergo dynamics and gradual changes in activity or concentration and thus may serve as temporal gradients. Recent studies have revealed that the gradual loss of Cdc25 protein, gradual depletion of free deoxyribonucleotide metabolites, or gradual depletion of free histone proteins impinge on Cdk1 activity in a threshold-like manner. In this review, we will highlight with a focus on Drosophila studies our current understanding and recent findings on the generation and readout of these temporal gradients, as well as their position within the regulatory network of the embryonic cell cycle.
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???displayArticle.link??? Biology (Basel)
???displayArticle.grants??? [+]
81871168 National Natural Science Foundation of China, GR1945/3-1, GR1945/15-1 and equipment grant INST 160/718-1 FUGG Deutsche Forschungsgemeinschaft
Genes referenced: cdk1 rasgrf1
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