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Mol Biol Evol
2021 Oct 27;3811:4934-4947. doi: 10.1093/molbev/msab218.
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Functional Evolution of a Bark Beetle Odorant Receptor Clade Detecting Monoterpenoids of Different Ecological Origins.
Hou XQ
,
Yuvaraj JK
,
Roberts RE
,
Zhang DD
,
Unelius CR
,
Löfstedt C
,
Andersson MN
.
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Insects detect odors using an array of odorant receptors (ORs), which may expand through gene duplication. How and which new functions may evolve among related ORs within a species remain poorly investigated. We addressed this question by functionally characterizing ORs from the Eurasian spruce bark beetle Ips typographus, in which physiological and behavioral responses to pheromones, volatiles from host and nonhost trees, and fungal symbionts are well described. In contrast, knowledge of OR function is restricted to two receptors detecting the pheromone compounds (S)-(-)-ipsenol (ItypOR46) and (R)-(-)-ipsdienol (ItypOR49). These receptors belong to an Ips-specific OR-lineage comprising seven ItypORs. To gain insight into the functional evolution of related ORs, we characterized the five remaining ORs in this clade using Xenopus oocytes. Two receptors responded primarily to the host tree monoterpenes (+)-3-carene (ItypOR25) and p-cymene (ItypOR27). Two receptors responded to oxygenated monoterpenoids produced in larger relative amounts by the beetle-associated fungi, with ItypOR23 specific for (+)-trans-(1R, 4S)-4-thujanol, and ItypOR29 responding to (+)-isopinocamphone and similar ketones. ItypOR28 responded to the pheromone E-myrcenol from the competitor Ips duplicatus. Overall, the OR responses match well with those of previously characterized olfactory sensory neuron classes except that neurons detecting E-myrcenol have not been identified. The characterized ORs are under strong purifying selection and demonstrate a shared functional property in that they all primarily respond to monoterpenoids. The variation in functional groups among OR ligands and their diverse ecological origins suggest that neofunctionalization has occurred early in the evolution of this OR-lineage following gene duplication.
Chinese Scholarship Council, 217-2014-689 Swedish Research Councils, Crafoord foundation, CTS 17:25 Carl Trygger Foundation, Royal Physiographic Society in Lund, AQ7 Max Planck Centre for Next Generation Chemical Ecology
Adipietro,
Functional evolution of mammalian odorant receptors.
2012, Pubmed
Adipietro,
Functional evolution of mammalian odorant receptors.
2012,
Pubmed
Andersson,
Antennal transcriptome analysis of the chemosensory gene families in the tree killing bark beetles, Ips typographus and Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae).
2013,
Pubmed
Andersson,
Genomic content of chemosensory genes correlates with host range in wood-boring beetles (Dendroctonus ponderosae, Agrilus planipennis, and Anoplophora glabripennis).
2019,
Pubmed
Andersson,
Peripheral modulation of pheromone response by inhibitory host compound in a beetle.
2010,
Pubmed
Andersson,
Specificity and redundancy in the olfactory system of the bark beetle Ips typographus: single-cell responses to ecologically relevant odors.
2009,
Pubmed
Anisimova,
Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution.
2001,
Pubmed
Antony,
Pheromone receptor of the globally invasive quarantine pest of the palm tree, the red palm weevil (Rhynchophorus ferrugineus).
2021,
Pubmed
Bastin-Héline,
A novel lineage of candidate pheromone receptors for sex communication in moths.
2019,
Pubmed
,
Xenbase
Biedermann,
Bark Beetle Population Dynamics in the Anthropocene: Challenges and Solutions.
2019,
Pubmed
Birgersson,
Quantitative variation of pheromone components in the spruce bark beetleIps typographus from different attack phases.
1984,
Pubmed
Carey,
Odorant reception in the malaria mosquito Anopheles gambiae.
2010,
Pubmed
Clyne,
A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.
1999,
Pubmed
Fleischer,
Access to the odor world: olfactory receptors and their role for signal transduction in insects.
2018,
Pubmed
Grosse-Wilde,
Candidate pheromone receptors provide the basis for the response of distinct antennal neurons to pheromonal compounds.
2007,
Pubmed
Guo,
Odorant Receptors for Detecting Flowering Plant Cues Are Functionally Conserved across Moths and Butterflies.
2021,
Pubmed
Hallem,
Coding of odors by a receptor repertoire.
2006,
Pubmed
Hansson,
Evolution of insect olfaction.
2011,
Pubmed
Hopf,
Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors.
2015,
Pubmed
,
Xenbase
Hou,
Functional characterization of odorant receptors from the moth Eriocrania semipurpurella: A comparison of results in the Xenopus oocyte and HEK cell systems.
2020,
Pubmed
,
Xenbase
Kandasamy,
Volatile organic compounds influence the interaction of the Eurasian spruce bark beetle (Ips typographus) with its fungal symbionts.
2019,
Pubmed
Katoh,
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.
2002,
Pubmed
Kausrud,
Trees wanted--dead or alive! Host selection and population dynamics in tree-killing bark beetles.
2011,
Pubmed
Leary,
Single mutation to a sex pheromone receptor provides adaptive specificity between closely related moth species.
2012,
Pubmed
,
Xenbase
Mansourian,
The chemical ecology of the fly.
2015,
Pubmed
McKenna,
Genome of the Asian longhorned beetle (Anoplophora glabripennis), a globally significant invasive species, reveals key functional and evolutionary innovations at the beetle-plant interface.
2016,
Pubmed
McKenzie,
Transcriptomics and neuroanatomy of the clonal raider ant implicate an expanded clade of odorant receptors in chemical communication.
2016,
Pubmed
Mitchell,
Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae.
2012,
Pubmed
,
Xenbase
Mitchell,
The diversity and evolution of odorant receptors in beetles (Coleoptera).
2020,
Pubmed
Nei,
The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity.
2008,
Pubmed
Pask,
Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones.
2017,
Pubmed
Price,
FastTree 2--approximately maximum-likelihood trees for large alignments.
2010,
Pubmed
Ramdya,
Evolving olfactory systems on the fly.
2010,
Pubmed
Rastogi,
Subfunctionalization of duplicated genes as a transition state to neofunctionalization.
2005,
Pubmed
Robertson,
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster.
2003,
Pubmed
Schiebe,
Inducibility of chemical defenses in Norway spruce bark is correlated with unsuccessful mass attacks by the spruce bark beetle.
2012,
Pubmed
Schiebe,
Styrene, (+)-trans-(1R,4S,5S)-4-Thujanol and Oxygenated Monoterpenes Related to Host Stress Elicit Strong Electrophysiological Responses in the Bark Beetle Ips typographus.
2019,
Pubmed
Schlyter,
Field response of spruce bark beetle,Ips typographus, to aggregation pheromone candidates.
1987,
Pubmed
Schlyter,
Inhibition of attraction to aggregation pheromone by verbenone and ipsenol : Density regulation mechanisms in bark beetleIps typographus.
1989,
Pubmed
Slone,
Functional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator.
2017,
Pubmed
Tømmerås,
Receptor cells inIps typographus andDendroctonus micans specific to pheromones of the reciprocal genus.
1984,
Pubmed
Unelius,
Non-host volatile blend optimization for forest protection against the European spruce bark beetle, Ips typographus.
2014,
Pubmed
Wang,
Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae.
2010,
Pubmed
,
Xenbase
Wang,
Three Host Plant Volatiles, Hexanal, Lauric Acid, and Tetradecane, are Detected by an Antenna-Biased Expressed Odorant Receptor 27 in the Dark Black Chafer Holotrichia parallela.
2020,
Pubmed
,
Xenbase
Yang,
PAML: a program package for phylogenetic analysis by maximum likelihood.
1997,
Pubmed
Yang,
Synonymous and nonsynonymous rate variation in nuclear genes of mammals.
1998,
Pubmed
Yuvaraj,
Functional characterization of odorant receptors from Lampronia capitella suggests a non-ditrysian origin of the lepidopteran pheromone receptor clade.
2018,
Pubmed
Yuvaraj,
Characterization of Odorant Receptors from a Non-ditrysian Moth, Eriocrania semipurpurella Sheds Light on the Origin of Sex Pheromone Receptors in Lepidoptera.
2017,
Pubmed
Yuvaraj,
Putative ligand binding sites of two functionally characterized bark beetle odorant receptors.
2021,
Pubmed
Zhang,
Functional evolution of a multigene family: orthologous and paralogous pheromone receptor genes in the turnip moth, Agrotis segetum.
2013,
Pubmed
,
Xenbase
Zhang,
Receptor for detection of a Type II sex pheromone in the winter moth Operophtera brumata.
2016,
Pubmed
Zhang,
Sequencing and characterization of six cDNAs putatively encoding three pairs of pheromone receptors in two sibling species, Helicoverpa armigera and Helicoverpa assulta.
2010,
Pubmed
Zhao,
Convergent evolution of semiochemicals across Kingdoms: bark beetles and their fungal symbionts.
2019,
Pubmed
Zhao,
The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies.
2010,
Pubmed
de Fouchier,
Functional evolution of Lepidoptera olfactory receptors revealed by deorphanization of a moth repertoire.
2017,
Pubmed
