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Antioxidants (Basel)
2021 Oct 17;1010:. doi: 10.3390/antiox10101636.
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Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development.
Lee H
,
Lee NY
,
Kim Y
,
Choi HS
,
Ismail T
,
Ryu HY
,
Cho DH
,
Ryoo ZY
,
Lee DS
,
Kwon TK
,
Park TJ
,
Kwon T
,
Lee HS
.
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Glutathione peroxidase 1 (Gpx1) and peroxiredoxin 2 (Prdx2) belong to the thiol peroxidase family of antioxidants, and have been studied for their antioxidant functions and roles in cancers. However, the physiological significance of Gpx1 and Prdx2 during vertebrate embryogenesis are lacking. Currently, we investigated the functional roles of Gpx1 and Prdx2 during vertebrate embryogenesis using Xenopus laevis as a vertebrate model. Our investigations revealed the zygotic nature of gpx1 having its localization in the eye region of developing embryos, whereas prdx2 exhibited a maternal nature and were localized in embryonic ventralblood islands. Furthermore, the gpx1-morphants exhibited malformed eyes with incompletely detached lenses. However, the depletion of prdx2 has not established its involvement with embryogenesis. A molecular analysis of gpx1-depleted embryos revealed the perturbed expression of a cryba1-lens-specific marker and also exhibited reactive oxygen species (ROS) accumulation in the eye regions of gpx1-morphants. Additionally, transcriptomics analysis of gpx1-knockout embryos demonstrated the involvement of Wnt, cadherin, and integrin signaling pathways in the development of malformed eyes. Conclusively, our findings indicate the association of gpx1 with a complex network of embryonic developmental pathways and ROS responses, but detailed investigation is a prerequisite in order to pinpoint the mechanistic details of these interactions.
Abouzeid,
Mutations in ALDH1A3 represent a frequent cause of microphthalmia/anophthalmia in consanguineous families.
2014, Pubmed
Abouzeid,
Mutations in ALDH1A3 represent a frequent cause of microphthalmia/anophthalmia in consanguineous families.
2014,
Pubmed
Alfano,
Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.
2011,
Pubmed
Bindoli,
Thiol chemistry in peroxidase catalysis and redox signaling.
2008,
Pubmed
Blum,
Xenopus, an ideal model system to study vertebrate left-right asymmetry.
2009,
Pubmed
,
Xenbase
Cadenas,
Mitochondrial free radical generation, oxidative stress, and aging.
2000,
Pubmed
Chae,
Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels.
2017,
Pubmed
,
Xenbase
Cheng,
GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer.
2019,
Pubmed
Covarrubias,
Function of reactive oxygen species during animal development: passive or active?
2008,
Pubmed
Donner,
Lens induction in vertebrates: variations on a conserved theme of signaling events.
2006,
Pubmed
Dringen,
Peroxide detoxification by brain cells.
,
Pubmed
Etzrodt,
Expression of classic cadherins and delta-protocadherins in the developing ferret retina.
2009,
Pubmed
Flach,
Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling.
2021,
Pubmed
,
Xenbase
Flentjar,
Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury.
2002,
Pubmed
Flohé,
A comparison of thiol peroxidase mechanisms.
2011,
Pubmed
Fokina,
Expression patterns of Wnt genes during development of an anterior part of the chicken eye.
2006,
Pubmed
Fujimura,
WNT/β-Catenin Signaling in Vertebrate Eye Development.
2016,
Pubmed
Halbleib,
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.
2006,
Pubmed
Hall,
Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
2011,
Pubmed
Han,
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
2012,
Pubmed
Ho,
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia.
1997,
Pubmed
Hu,
GPX1 Pro198Leu polymorphism and breast cancer risk: a meta-analysis.
2010,
Pubmed
Imlay,
Pathways of oxidative damage.
2003,
Pubmed
Ji,
Peroxiredoxin5 Controls Vertebrate Ciliogenesis by Modulating Mitochondrial Reactive Oxygen Species.
2019,
Pubmed
,
Xenbase
Kim,
Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development.
2018,
Pubmed
,
Xenbase
Lee,
Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice.
2003,
Pubmed
Lee,
Xenopus gpx3 Mediates Posterior Development by Regulating Cell Death during Embryogenesis.
2020,
Pubmed
,
Xenbase
Li,
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
2021,
Pubmed
Liu,
Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
2018,
Pubmed
Low,
Peroxiredoxin 2 and peroxide metabolism in the erythrocyte.
2008,
Pubmed
Lubos,
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.
2011,
Pubmed
Min,
Prognostic significance of glutathione peroxidase 1 (GPX1) down-regulation and correlation with aberrant promoter methylation in human gastric cancer.
2012,
Pubmed
Mohammedi,
Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes.
2016,
Pubmed
NULL,
Shaping embryonic development.
2017,
Pubmed
Nakamura,
Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.
2002,
Pubmed
Rhee,
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides.
2012,
Pubmed
Rhee,
Peroxiredoxin, a novel family of peroxidases.
2001,
Pubmed
Robinson,
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
2010,
Pubmed
Schieber,
ROS function in redox signaling and oxidative stress.
2014,
Pubmed
Seigfried,
Frizzled 3 acts upstream of Alcam during embryonic eye development.
2017,
Pubmed
,
Xenbase
Timme-Laragy,
Redox stress and signaling during vertebrate embryonic development: Regulation and responses.
2018,
Pubmed
Ufer,
The Roles of Glutathione Peroxidases during Embryo Development.
2011,
Pubmed
Valko,
Free radicals and antioxidants in normal physiological functions and human disease.
2007,
Pubmed
Van Raay,
Wnt/frizzled signaling during vertebrate retinal development.
2004,
Pubmed
Walker,
Integrins in lens development and disease.
2009,
Pubmed
Wang,
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
2021,
Pubmed
Wei,
Expression and prognostic potential of GPX1 in human cancers based on data mining.
2020,
Pubmed
Yang,
Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo.
2018,
Pubmed
Zigler,
βA3/A1-crystallin: more than a lens protein.
2015,
Pubmed
