Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Int J Mol Sci
2021 Dec 21;231:. doi: 10.3390/ijms23010031.
Show Gene links
Show Anatomy links
Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review.
Closset M
,
Cailliau K
,
Slaby S
,
Marin M
.
???displayArticle.abstract???
Aluminium (Al) is the most common natural metallic element in the Earth's crust. It is released into the environment through natural processes and human activities and accumulates in aquatic environments. This review compiles scientific data on the neurotoxicity of aluminium contamination on the nervous system of aquatic organisms. More precisely, it helps identify biomarkers of aluminium exposure for aquatic environment biomonitoring in freshwater aquatic vertebrates. Al is neurotoxic and accumulates in the nervous system of aquatic vertebrates, which is why it could be responsible for oxidative stress. In addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. It also causes histological changes in nerve tissue, modifications of organism behaviour, and cognitive deficit. However, impacts of aluminium exposure on the early stages of aquatic vertebrate development are poorly described. Lastly, this review also poses the question of how accurate aquatic vertebrates (fishes and amphibians) could be used as model organisms to complement biological data relating to the developmental aspect. This "challenge" is very relevant since freshwater pollution with heavy metals has increased in the last few decades.
Allin,
Effects of pre-acclimation to aluminium on the physiology and swimming behaviour of juvenile rainbow trout (Oncorhynchus mykiss) during a pulsed exposure.
2000, Pubmed
Allin,
Effects of pre-acclimation to aluminium on the physiology and swimming behaviour of juvenile rainbow trout (Oncorhynchus mykiss) during a pulsed exposure.
2000,
Pubmed
Amador,
Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals.
2001,
Pubmed
Atli,
Response of catalase activity to Ag+, Cd2+, Cr6+, Cu2+ and Zn2+ in five tissues of freshwater fish Oreochromis niloticus.
2006,
Pubmed
Beketov,
Pesticides reduce regional biodiversity of stream invertebrates.
2013,
Pubmed
Borodinsky,
Xenopus laevis as a Model Organism for the Study of Spinal Cord Formation, Development, Function and Regeneration.
2017,
Pubmed
,
Xenbase
Brodeur,
Effects of subchronic exposure to aluminium in acidic water on bioenergetics of Atlantic salmon (Salmo salar).
2001,
Pubmed
Browne,
Reduced glutathione and glutathione disulfide.
1998,
Pubmed
Calevro,
Tests of toxicity and teratogenicity in biphasic vertebrates treated with heavy metals (Cr3+, Al3+, Cd2+).
1998,
Pubmed
Camargo,
How aluminium exposure promotes osmoregulatory disturbances in the neotropical freshwater fish Prochilus lineatus.
2009,
Pubmed
Capriello,
Effects of aluminium and cadmium on hatching and swimming ability in developing zebrafish.
2019,
Pubmed
Correia,
Aluminum as an endocrine disruptor in female Nile tilapia (Oreochromis niloticus).
2010,
Pubmed
Cummins,
Effects of aluminium and low pH on growth and development in Rana temporaria tadpoles.
1986,
Pubmed
Dudgeon,
Multiple threats imperil freshwater biodiversity in the Anthropocene.
2019,
Pubmed
Erdogan,
Using Xenopus laevis retinal and spinal neurons to study mechanisms of axon guidance in vivo and in vitro.
2016,
Pubmed
,
Xenbase
Fernández-Dávila,
Aluminum-induced oxidative stress and neurotoxicity in grass carp (Cyprinidae--Ctenopharingodon idella).
2012,
Pubmed
Ganrot,
Metabolism and possible health effects of aluminum.
1986,
Pubmed
Goenaga,
Aluminium speciation in surface waters from a Welsh upland area.
1988,
Pubmed
Grassie,
Aluminum exposure impacts brain plasticity and behavior in Atlantic salmon (Salmo salar).
2013,
Pubmed
Gulya,
Cholinotoxic effects of aluminum in rat brain.
1990,
Pubmed
Guo,
Using zebrafish to assess the impact of drugs on neural development and function.
2009,
Pubmed
Gurdon,
The introduction of Xenopus laevis into developmental biology: of empire, pregnancy testing and ribosomal genes.
2000,
Pubmed
,
Xenbase
Harland,
Xenopus research: metamorphosed by genetics and genomics.
2011,
Pubmed
,
Xenbase
Herkovits,
Living organisms influence on environmental conditions: pH modulation by amphibian embryos versus aluminum toxicity.
2015,
Pubmed
Hill,
Zebrafish as a model vertebrate for investigating chemical toxicity.
2005,
Pubmed
Igbokwe,
Aluminium toxicosis: a review of toxic actions and effects.
2019,
Pubmed
Jena,
Age-related effect of aluminium on the catalase activities of the brains of two species of poikilothermic vertebrates.
2002,
Pubmed
Jones,
Exposure of man to environmental aluminium--an exposure commitment assessment.
1986,
Pubmed
Kaizer,
Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions.
2005,
Pubmed
Laming,
Epileptogenesis is associated with heightened arousal responses in fish.
1987,
Pubmed
Lari,
Binding of Al(iii) to synthetic RNA and metal-mediated strand aggregation.
2017,
Pubmed
Lee,
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.
1995,
Pubmed
,
Xenbase
Meng,
Identifying geogenic and anthropogenic controls on different spatial distribution patterns of aluminium, calcium and lead in urban topsoil of Greater London Authority area.
2020,
Pubmed
Monaco,
Aluminium chloride-induced toxicity in zebrafish larvae.
2017,
Pubmed
Monastersky,
Biodiversity: Life--a status report.
2014,
Pubmed
Monette,
Impacts of short-term acid and aluminum exposure on Atlantic salmon (Salmo salar) physiology: a direct comparison of parr and smolts.
2008,
Pubmed
Nam,
Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress.
2016,
Pubmed
Nelson,
The effects of acidification on the geochemistry of Al, Cd, Pb and Hg in freshwater environments: a literature review.
1991,
Pubmed
Nishimura,
Zebrafish as a systems toxicology model for developmental neurotoxicity testing.
2015,
Pubmed
Oberholster,
Bioaccumulation of aluminium and iron in the food chain of Lake Loskop, South Africa.
2012,
Pubmed
Oliveira,
Aluminium sulfate exposure: A set of effects on hydrolases from brain, muscle and digestive tract of juvenile Nile tilapia (Oreochromis niloticus).
2017,
Pubmed
Pepeu,
Changes in acetylcholine extracellular levels during cognitive processes.
2004,
Pubmed
Pereira,
Comparative genotoxicity of aluminium and cadmium in embryonic zebrafish cells.
2013,
Pubmed
Pratt,
Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.
2013,
Pubmed
,
Xenbase
Rosseland,
Environmental effects of aluminium.
1990,
Pubmed
Scott,
The effects of environmental pollutants on complex fish behaviour: integrating behavioural and physiological indicators of toxicity.
2004,
Pubmed
Semsei,
Expression of superoxide dismutase and catalase in rat brain as a function of age.
1991,
Pubmed
Senger,
Aluminum exposure alters behavioral parameters and increases acetylcholinesterase activity in zebrafish (Danio rerio) brain.
2011,
Pubmed
Sfakianakis,
Effect of heavy metals on fish larvae deformities: A review.
2015,
Pubmed
Shaman,
Hyperphosphatemia Management in Patients with Chronic Kidney Disease.
2016,
Pubmed
Shi,
Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity.
2019,
Pubmed
Singla,
Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain.
2014,
Pubmed
Sivakumar,
Bioaccumulations of aluminum and the effects of chelating agents on different organs of Cirrhinus mrigala.
2012,
Pubmed
Slaby,
Exposures to chemical contaminants: What can we learn from reproduction and development endpoints in the amphibian toxicology literature?
2019,
Pubmed
,
Xenbase
Sohal,
Effect of hydrogen peroxide administration on life span, superoxide dismutase, catalase, and glutathione in the adult housefly, Musca domestica.
1988,
Pubmed
Sparling,
Environmental hazards of aluminum to plants, invertebrates, fish, and wildlife.
1996,
Pubmed
Stephens,
Two cases of fish mortality in low pH, aluminium rich water.
2006,
Pubmed
Turner,
Molecular dynamics simulation of aluminium binding to amyloid-β and its effect on peptide structure.
2019,
Pubmed
Valko,
Free radicals and antioxidants in normal physiological functions and human disease.
2007,
Pubmed
Vontas,
Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens.
2001,
Pubmed
Wang,
Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain.
2014,
Pubmed
Wei,
Effect of Aluminum Exposure on Glucose Metabolism and Its Mechanism in Rats.
2018,
Pubmed
Wheeler,
Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.
2009,
Pubmed
,
Xenbase
Witters,
Chemical speciation dynamics and toxicity assessment in aquatic systems.
1998,
Pubmed
Wu,
Thermodynamics of the interaction of aluminum ions with DNA: implications for the biological function of aluminum.
2005,
Pubmed
Yang,
The stabilization of ferrous iron by a toxic beta-amyloid fragment and by an aluminum salt.
1999,
Pubmed
Zhang,
Iron Dyshomeostasis Participated in Rat Hippocampus Toxicity Caused by Aluminum Chloride.
2020,
Pubmed
d'Amora,
The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity.
2018,
Pubmed
van der Oost,
Fish bioaccumulation and biomarkers in environmental risk assessment: a review.
2003,
Pubmed