Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-58871
Adv Exp Med Biol 2022 Jan 01;1360:23-39. doi: 10.1007/978-3-030-94804-7_2.
Show Gene links Show Anatomy links

Roles for GADD45 in Development and Cancer.

Patel K , Murray MG , Whelan KA .


???displayArticle.abstract???
The Growth Arrest and DNA Damage-inducible 45 (GADD45) family of proteins are critical stress sensors that mediate various cellular responses, including DNA repair, cell cycle arrest, and apoptosis. Here, we review current literature investigating GADD45 family members as they relate to normal development and carcinogenesis. We first describe how modulation of GADD45 in model organisms has facilitated our understanding of roles for GADD45 family members in development and homeostasis. We then review current literature exploring roles for GADD45 in human cancer, describing cancer-associated alterations in expression of GADD45 family members; tumor suppressive and tumor promoting functions attributed to GADD5; and roles for GADD45 in cancer therapy. In exploring roles for GADD45 in development, homeostasis, and carcinogenesis, we aim to provide an informational resource that both highlighst current knowledge on this topic while also noting key gaps in our understanding of the biology of GADD45 that may be filled in order to best guide the development of novel approaches to improve diagnosis, monitoring, and therapy of human malignancies.

???displayArticle.pubmedLink??? 35505160
???displayArticle.link??? Adv Exp Med Biol



References [+] :
Asuthkar, Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT. 2011, Pubmed