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XB-ART-59210
Dev Growth Differ August 1, 2022; 64 (6): 297-305.
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Foxh1 engages in chromatin regulation revealed by protein interactome analyses.

Zhou JJ , Pham PD , Han H , Wang W , Cho KWY .


Abstract
Early embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.

PubMed ID: 35848281
Article link: Dev Growth Differ
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: eed ezh2 foxa2 foxh1 foxh1.2 gapdh hdac1 npat pax6 pou5f3.1 smad2 smad3 suz12 tbxt
GO keywords: chromatin organization [+]
Morpholinos: foxh1 MO2

GEO Series: GSE204990: NCBI

Article Images: [+] show captions
References [+] :
Amin, RNA-seq in the tetraploid Xenopus laevis enables genome-wide insight in a classic developmental biology model organism. 2015, Pubmed, Xenbase