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XB-ART-59364
Neuroscientist 2021 Feb 01;271:58-72. doi: 10.1177/1073858420914509.
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Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases.

Gao J , Liao Y , Qiu M , Shen W .


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Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator β-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/β-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/β-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer's disease, Parkinson's disease, and depression.

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