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Dev Dyn December 1, 2002; 225 (4): 469-84.
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Early embryonic expression of ion channels and pumps in chick and Xenopus development.

Rutenberg J , Cheng SM , Levin M .

An extensive body of literature implicates endogenous ion currents and standing voltage potential differences in the control of events during embryonic morphogenesis. Although the expression of ion channel and pump genes, which are responsible for ion flux, has been investigated in detail in nervous tissues, little data are available on the distribution and function of specific channels and pumps in early embryogenesis. To provide a necessary basis for the molecular understanding of the role of ion flux in development, we surveyed the expression of ion channel and pump mRNAs, as well as other genes that help to regulate membrane potential. Analysis in two species, chick and Xenopus, shows that several ion channel and pump mRNAs are present in specific and dynamic expression patterns in early embryos, well before the appearance of neurons. Examination of the distribution of maternal mRNAs reveals complex spatiotemporal subcellular localization patterns of transcripts in early blastomeres in Xenopus. Taken together, these data are consistent with an important role for ion flux in early embryonic morphogenesis; this survey characterizes candidate genes and provides information on likely embryonic contexts for their function, setting the stage for functional studies of the morphogenetic roles of ion transport.

PubMed ID: 12454924
Article link: Dev Dyn

Species referenced: Xenopus
Genes referenced: aqp4 arfgap1 atp1a1 atp6ap1.1 atp6v0c atp6v0d2 cx38 dmbt1 gja4 gja5 gjb3 kcna1 kcnb2 kcnip2 kcnip4 kcnj3 kcnj5 kcnj8 magainins vegt

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