Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-6794
Microb Pathog 2002 Jun 01;326:273-7. doi: 10.1006/mpat.2002.0502.
Show Gene links Show Anatomy links

Positive and negative regulation of water channel aquaporins in human small intestine by cholera toxin.

Hamabata T , Liu C , Takeda Y .


???displayArticle.abstract???
Analysis of osmotic water permeability of aquaporin (AQP) 1, AQP3 and AQP4, which are expressed in human small intestine, in the presence or absence of cholera toxin (CT) was performed using a Xenopus oocyte expression system. When treated with CT, water permeability of AQP4 was facilitated while that of AQP3 was suppressed. AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration. A possibility that these AQPs are responsible molecules for causing acute secretory diarrhoea as in cholera is considered.

???displayArticle.pubmedLink??? 12137754
???displayArticle.link??? Microb Pathog


Species referenced: Xenopus
Genes referenced: aqp1 aqp3 aqp4 camp