XB-ART-6912
Nature
2002 Jul 04;4186893:37-8. doi: 10.1038/418037a.
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Conserved function for embryonic nodal cilia.
Abstract
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
PubMed ID: 12097899
Article link: Nature
Species referenced: Xenopus
Genes referenced: nodal nodal1
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