Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Dyn
2006 Mar 01;2353:586-93. doi: 10.1002/dvdy.20688.
Show Gene links
Show Anatomy links
Bves, a member of the Popeye domain-containing gene family.
Osler ME
,
Smith TK
,
Bader DM
.
???displayArticle.abstract??? Bves was discovered through subtractive screens designed to identify heart-enriched transcripts. Bves is a transmembrane protein that possesses a highly conserved structure among species of the animal kingdom. Various approaches have been used to elucidate the expression pattern of Bves mRNA and protein as well as its function in developing and mature organisms. Emerging evidence indicates that this protein is present in muscle and epithelia of developing embryos and the adult. In vitro functional studies predict a role in cell-cell interaction and/or adhesion. In vivo analysis of protein function is very limited at present, but recent work in Xenopus supports the importance of Bves in epithelial integrity. Presented in this review is a compilation of published findings concerning Bves gene and protein characteristics, expression patterns in embryos and cells, and functional significance as determined thus far. Presently, the literature supports a hypothesis that Bves is essential to the junctional architecture of muscle and epithelial cell types. Although there remain aspects of Bves structure, expression, and function that are not completely resolved, now is an appropriate time to summarize current knowledge about this protein, the remaining questions, and what its potential role in development might be. This review will serve as a departure point for others who become interested in the study of this highly conserved protein.
Fig. 2. Bves expression in muscle and epithelia. A: B846 polyclonal immunoreagent detects Bves (red) in the epithelial epicardium (epic), delaminated
migratory cells (arrows), and myocardium (myo) in a section through a developing chick heart. Smooth muscle actin (green) labels forming coronary
vessels (cv) in the subepicardial space. B: Five-day frog embryo labeled with -XBves (green). Positive cells are found in the epidermis (ep), the
developing heart (h), and the velar plate (arrows). C: Bves is distributed at the cell circumference in cultured human corneal epithelial cells, as labeled
by B846 polyclonal antisera. D: Bves is detected by -Bves B846 (red) in the serosa (ser), the smooth muscle (sm), and the gastric epithelium (arrows)
of the adult mouse intestine. The 4 ,6-diamidine-2-phenylidole-dihydrochloride (DAPI) labels the cell nuclei (blue). E: -XBves detects epithelium
(arrows) and the smooth muscle (sm) cells of the adult Xenopus gut (green). F: Xenopus Bves is recognized by -XBves in the epithelial layers of the
adult frog eye, including the cornea (cor) and retina (ret).
Andrée,
Molecular and functional analysis of Popeye genes: A novel family of transmembrane proteins preferentially expressed in heart and skeletal muscle.
2002, Pubmed
Andrée,
Molecular and functional analysis of Popeye genes: A novel family of transmembrane proteins preferentially expressed in heart and skeletal muscle.
2002,
Pubmed
Andrée,
Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart.
2000,
Pubmed
Andrée,
Mouse Pop1 is required for muscle regeneration in adult skeletal muscle.
2002,
Pubmed
Barber,
Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
2002,
Pubmed
Barker,
Increased co-localization of connexin43 and ZO-1 in dissociated adult myocytes.
2001,
Pubmed
Brand,
The Popeye domain-containing gene family.
2005,
Pubmed
Breher,
Popeye domain containing gene 2 (Popdc2) is a myocyte-specific differentiation marker during chick heart development.
2004,
Pubmed
Davidson,
Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis.
2003,
Pubmed
Davidson,
A morphological and genetic characterization of metamorphosis in the ascidian Boltenia villosa.
2003,
Pubmed
DiAngelo,
Production of monoclonal antibodies against chicken Pop1 (BVES).
2001,
Pubmed
Fanning,
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.
1998,
Pubmed
Hitz,
Cardiac specific expression of Xenopus Popeye-1.
2002,
Pubmed
,
Xenbase
Itoh,
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.
1999,
Pubmed
Itoh,
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.
1993,
Pubmed
Knight,
Membrane topology of Bves/Pop1A, a cell adhesion molecule that displays dynamic changes in cellular distribution during development.
2003,
Pubmed
Osler,
Bves expression during avian embryogenesis.
2004,
Pubmed
Osler,
Bves modulates epithelial integrity through an interaction at the tight junction.
2005,
Pubmed
Reese,
bves: A novel gene expressed during coronary blood vessel development.
1999,
Pubmed
Reese,
Cloning and expression of hbves, a novel and highly conserved mRNA expressed in the developing and adult heart and skeletal muscle in the human.
1999,
Pubmed
Ripley,
Bves is expressed in the epithelial components of the retina, lens, and cornea.
2004,
Pubmed
Ripley,
Xbves is a regulator of epithelial movement during early Xenopus laevis development.
2006,
Pubmed
,
Xenbase
Vasavada,
Developmental expression of Pop1/Bves.
2004,
Pubmed
Wada,
Bves: prototype of a new class of cell adhesion molecules expressed during coronary artery development.
2001,
Pubmed
