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XB-ART-7777
Mol Cells December 31, 2001; 12 (3): 342-6.
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Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes.

Jung SY , Choi S , Ko YS , Park CS , Oh S , Koh SR , Oh U , Oh JW , Rhee MH , Nah SY .


Abstract
Ginsenosides, or ginseng saponins, are biologically active ingredients of Panax ginseng. Accumulating evidence suggests that ginsenosides can alleviate pain from injections of noxious chemicals, such as capsaicin [Nah et al. (2000)]. In this study we examined the effects of ginsenoside Rc on the capsaicin-induced inward current in Xenopus oocytes that expresses the vanilloid receptor 1 (VR1). Ginsenoside Rc enhanced the capsaicin-induced inward current in a concentration-dependent and reversible manner, but ginsenoside Rc itself elicited no membrane currents. The VR1 antagonist capsazepine almost completely blocked the inward current that was elicited by capsaicin plus ginsenoside Rc. We also tested the effect of seven other fractionated ginsenosides (i.e., Rb1, Rb2, Rd, Re, Rf, Rg1, and Rg2) in addition to ginsenoside Rc. We found that six of them significantly enhanced the inward current that is induced by capsaicin with the following order of potency: Rc > Rf > Rg1 approximately Rd > Rb2 > Rb1. These results show the possibility that the in vivo effect of ginsenosides against capsaicin-induced pain is derived from their modulation of the VR1 channel function.

PubMed ID: 11804333
Article link: Mol Cells


Species referenced: Xenopus laevis
Genes referenced: rb1 rbl2 tbx2