XB-ART-8052
FEBS Lett
2001 Nov 16;5082:170-4. doi: 10.1016/s0014-5793(01)03027-7.
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Molecular cloning of the cDNA coding for Xenopus laevis prion protein.
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Isolation and characterization of the cDNA coding for the 216-residue Xenopus laevis prion protein is reported. Existence of this protein in amphibians was suggested by an EST fragment (accession number BG813008), while a conclusive demonstration is presented here. This protein exhibits a higher identity level to avian and turtle prion (more than 44%) than to mammalian prion (about 28%). Although most of the structural motifs common to known prion proteins are conserved in X. laevis, the lack of repeats represents a substantial difference. Other features worth noting are the presence of not perfectly conserved hydrophobic stretch, which is considered the prion signature, as well as the complete absence of histidine residues.
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Species referenced: Xenopus laevis
Genes referenced: prnp