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XB-ART-9405
FEBS Lett 2001 Mar 09;4921-2:20-8. doi: 10.1016/s0014-5793(01)02220-7.
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Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5.

Keren-Raifman T , Bera AK , Zveig D , Peleg S , Witherow DS , Slepak VZ , Dascal N .


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Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K(+) channels (GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression, we reveal biphasic effects of RGSs on GIRK regulation. At low concentrations, RGS4 inhibited basal GIRK activity, but stimulated it at high concentrations. RGS7, which is associated with the G protein subunit G beta 5, is regulated by G beta 5 by two distinct mechanisms. First, G beta 5 augments RGS7 activity, and second, it increases its expression. These dual effects resolve previous controversies regarding RGS4 and RGS7 function and indicate that they modulate signaling by mechanisms supplementary to their GTPase-activating protein activity.

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Species referenced: Xenopus laevis
Genes referenced: kcnj3 rgs4