Figure 1 – Ten of the genes identified as exhibiting rax-dependent expression are expressed in the developing eye. A – J: Xenopus laevis embryos were fixed and subjected to in situ hybridization using antisense riboprobes specific for 10 of the genes identified as exhibiting rax-dependent expression in the microarray screen described in the text. Genes/riboprobes are identified to the left of each row. Embryos used were late neurula (st 18 – 20, column 1), with the exception of J1 (st 22), early tailbud (st 24 and 25, column 2), mid tailbud (st 25 – 31, column 3), and mid-late tailbud (st 30 – 33, column 4). Lateral views are shown for all embryos except for A1, B1, C1, D1, G1, H1, I1, where anterior views are shown. In all cases, dorsal is towards the top of the figure. Abbreviations and marks: arrowhead – eye; * - brain; B – branchial arches; P – pronephros.
Image published in: Pan Y et al. (2018)
Copyright © 2018. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| abcf2.L | abc28, hussy-18, hussy18, LOC101731820, m-abc1 | X. laevis | Throughout NF stage 20 | eye primordium optic field neural plate |
| cbx5.L | HP1-a, HP1-alpha, HP1a, HP1alpha | X. laevis | Sometime during NF stage 18 to NF stage 24 | optic vesicle |
| XB5768883.L | LOC100498624, MGC86492 | X. laevis | Throughout NF stage 18 | |
| cox4i1.L | cox4, coxiv | X. laevis | Throughout NF stage 20 | eye primordium optic field |
| neil3.L | X. laevis | Sometime during NF stage 20 to NF stage 24 | optic vesicle eye eye primordium | |
| e2f7.L | X. laevis | Throughout NF stage 26 | optic vesicle eye primordium | |
| fam50a.S | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 18 | optic vesicle eye primordium neural plate pre-chordal neural plate chordal neural plate cranial neural crest |
| bnip3.L | X. laevis | Throughout NF stage 18 | optic vesicle eye primordium optic field neural plate pre-chordal neural plate chordal neural plate | |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Throughout NF stage 18 | eye primordium optic field neural plate pre-chordal neural plate |
| fam50a.L | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 22 | eye primordium optic field |
| abcf2.L | abc28, hussy-18, hussy18, LOC101731820, m-abc1 | X. laevis | Sometime during NF stage 24 to NF stage 25 | optic vesicle eye |
| abcf2.L | abc28, hussy-18, hussy18, LOC101731820, m-abc1 | X. laevis | Throughout NF stage 28 | eye pharyngeal arch |
| abcf2.L | abc28, hussy-18, hussy18, LOC101731820, m-abc1 | X. laevis | Throughout NF stage 29 and 30 | eye central nervous system pharyngeal arch |
| cbx5.L | HP1-a, HP1-alpha, HP1a, HP1alpha | X. laevis | Throughout NF stage 26 | eye olfactory bulb |
| cbx5.L | HP1-a, HP1-alpha, HP1a, HP1alpha | X. laevis | Throughout NF stage 32 | eye olfactory bulb |
| XB5768883.L | LOC100498624, MGC86492 | X. laevis | Throughout NF stage 24 | trigeminal nerve neural tube |
| XB5768883.L | LOC100498624, MGC86492 | X. laevis | Throughout NF stage 29 and 30 | eye |
| XB5768883.L | LOC100498624, MGC86492 | X. laevis | Throughout NF stage 33 and 34 | eye central nervous system spinal cord brain forebrain midbrain hindbrain |
| cox4i1.L | cox4, coxiv | X. laevis | Throughout NF stage 25 | optic vesicle eye |
| cox4i1.L | cox4, coxiv | X. laevis | Throughout NF stage 28 | optic vesicle eye central nervous system spinal cord brain hindbrain pronephric mesenchyme |
| cox4i1.L | cox4, coxiv | X. laevis | Throughout NF stage 32 | eye central nervous system spinal cord brain forebrain midbrain hindbrain pronephric kidney pronephric nephron pronephric tubule proximal tubule |
| neil3.L | X. laevis | Throughout NF stage 26 | optic vesicle eye | |
| neil3.L | X. laevis | Throughout NF stage 29 and 30 | eye | |
| e2f7.L | X. laevis | Throughout NF stage 31 | eye brain forebrain midbrain hindbrain otic vesicle | |
| e2f7.L | X. laevis | Throughout NF stage 33 and 34 | eye brain forebrain midbrain hindbrain | |
| fam50a.S | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 25 | optic vesicle eye cranial neural crest neural tube |
| fam50a.S | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Sometime during NF stage 28 to NF stage 32 | optic vesicle eye central nervous system spinal cord brain forebrain midbrain hindbrain pharyngeal arch |
| bnip3.L | X. laevis | Throughout NF stage 25 | optic vesicle eye neural tube posterior neural tube | |
| bnip3.L | X. laevis | Throughout NF stage 33 and 34 | eye brain forebrain midbrain hindbrain | |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Sometime during NF stage 26 to NF stage 28 | optic vesicle eye eye primordium brain forebrain midbrain hindbrain |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Throughout NF stage 32 | eye brain forebrain midbrain hindbrain pharyngeal arch |
| fam50a.L | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 24 | optic vesicle eye |
| fam50a.L | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 26 | eye trunk |
| fam50a.L | fam50a-a, fam50a-b, hxc-26, xap5 | X. laevis | Throughout NF stage 33 and 34 | eye brain forebrain midbrain hindbrain pharyngeal arch trunk |
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