fig. 4 CDEF

Ismail T et al. (2024)

Xla Wt +PFOS

NF35/36-37/38 (RNA-Seq)

Anatomical Phenotype
abnormal arginine metabolic process abnormal ATP metabolic process abnormal ornithine metabolic process

Expression Phenotype

decreased amount rho.L expression in embryo
increased amount mmp1.L expression in the embryo
increased amount olfm4.L expression in the embryo
decreased amount chad.L expression in embryo
decreased amount col8a2.L expression in embryo
decreased amount pax1.L expression in embryo
increased amount cel.L expression in embryo
increased amount cela1.L expression in embryo
increased amount cpb1.L expression in embryo
increased amount prss2.L expression in embryo

XB-PHENO-26228

Bocquet B et al. (2023)

tbc1d32 MO2 + NF St 3

NF St 35-36 in situ hybridization

Expression Phenotype
decreased amount rho.L expression in retina decreased amount rho.L expression in retinal cone cell

XB-PHENO-26227

Bocquet B et al. (2023)

tbc1d32 MO2 + NF St 3

NF St 35-36 whole-mount microscopy

Expression Phenotype
decreased amount rho.L expression in retina

XB-PHENO-26210

Bocquet B et al. (2023)

tbc1d32 MO3 + NF St 3

NF St 40 immunohistochemistry

Expression Phenotype
decreased amount rho.L expression in retina decreased amount rho.L expression in retinal cone cell decreased amount opn1sw.L expression in retina decreased amount opn1sw.L expression in retinal cone cell

XB-PHENO-25420

Flach H et al. (2021)

Xla Wt + rbp1 MO1

NF42

Anatomical Phenotype
abnormal retinal layer abnormal retinal layer morphology abnormal retinal pigmented epithelium morphology

Expression Phenotype
decreased amount rho.L expression in retina decreased amount pax6.L expression in retina decreased amount pou1f1.L expression in retina decreased amount prox1.L expression in retina decreased amount vsx1.L expression in retina

Fig.1.B

Feehan JM et al. (2017)

Xla Wt + rho CRISPR

NF49 (immunohistochemistry)

Anatomical Phenotype
abnormal photoreceptor layer morphology abnormal retinal rod cell morphology absent retinal rod cell

Expression Phenotype
decreased amount rho.L expression in photoreceptor layer

Fig2.B

Feehan JM et al. (2017)

Xla Wt + rho CRISPR

NF49 (immunohistochemistry)

Anatomical Phenotype
abnormal photoreceptor layer morphology abnormal retinal rod cell morphology absent retinal rod cell

Expression Phenotype
decreased amount rho.L expression in photoreceptor layer

Fig.2.B

Feehan JM et al. (2017)

Xla Wt + rho CRISPR

NF49 (immunohistochemistry)

Anatomical Phenotype
abnormal photoreceptor layer morphology abnormal retinal rod cell morphology absent retinal rod cell

Expression Phenotype
decreased amount rho.L expression in photoreceptor layer

Fig.1.A

Feehan JM et al. (2017)

Xla Wt + rho CRISPR

NF49 (Other Detection Assay)

Expression Phenotype
decreased amount rho.L expression in eye

Fig.2.A

Feehan JM et al. (2017)

Xla Wt + rho CRISPR

NF49 (Other Detection Assay)

Expression Phenotype
decreased amount rho.L expression in eye