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XB-PHENO-23396

Xla Wt + sipa1l3 MO, Rothe M et al. (2017)

Experiment + Assay: Xla Wt + sipa1l3 MO + NF42 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection sipa1l3 MO1 sipa1l3.L
sipa1l3.S
 NF stage 4 (8-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 42  
Anatomical Phenotypes: abnormal development of eye , abnormal development of retinal layer , abnormal retinal ganglion cell layer morphology , abnormally localised retinal ganglion cell layer , abnormally localised retinal inner nuclear layer
Expression Phenotypes (9):
increased amount pax6.L expression in amacrine cell
mislocalised pax6.L expression in photoreceptor layer
increased amount pax6.L expression in retinal ganglion cell layer
mislocalised pax6.L expression in retinal inner nuclear layer
increased amount pou4f1.L expression in retinal ganglion cell layer
decreased amount rho.L expression in photoreceptor layer
mislocalised rho.L expression in retinal inner nuclear layer
mislocalised vsx1.L expression in retinal ganglion cell layer
increased amount vsx1.L expression in retinal inner nuclear layer
Source: fig.S2.a
Article: XB-ART-52888, PubMed