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XB-PHENO-24169

Xla Wt + chd1 CRISPR, Wyatt BH et al. (2021)

Experiment + Assay: Xla Wt + chd1 CRISPR + NF42-43 (whole-mount microscopy)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR chd1 (Xla) chd1 (Xla)
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
whole-mount microscopy NF stage 42 to NF stage 43  
Anatomical Phenotypes: abnormal alimentary system morphology , abnormal craniofacial region morphology , abnormal heart morphology , abnormal tail morphology , decreased size of the intercanthal region , decreased width of the mouth
Human Disease Associations: orofacial cleft
Source: Fig. 3 t-w
Article: XB-ART-57345, PubMed