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Xla Wt + ptpn11N308D, Langdon Y et al. (2012)

Experiment + Assay: Xla Wt + ptpn11N308D + NF35/36 (immunohistochemistry)
Background: Xla.Outbred
Manipulation Type Reagent Target Gene Stage Treatment Area
DNA injection Tg(ptpn11N308D) ptpn11 (Xla)
NF stage 1 embryo
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 35 and 36 Tpm1 Ab1
Anatomical Phenotypes: abnormal cardiac atrium, abnormal cardiac ventricle, abnormal heart looping, abnormal heart morphology, decreased size of the heart
Human Disease Associations: Noonan syndrome
Source: Fig. 1 FG
Article: XB-ART-44762, PubMed