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Xla Wt + ptpn11N308D, Langdon Y et al. (2012)

Experiment + Assay: Xla Wt + ptpn11N308D + NF33/34 (3D imaging)
Background: Xla.Outbred
Manipulation Type Reagent Target Gene Stage Treatment Area
DNA injection Tg(ptpn11N308D) ptpn11 (Xla)
NF stage 1 embryo
Assay Type Assay Stages Antibody
3D imaging NF stage 33 and 34  
Anatomical Phenotypes: abnormal heart morphology, abnormally decreased number of cardiac myocyte
Human Disease Associations: Noonan syndrome
Source: Fig. 2 DJ
Article: XB-ART-44762, PubMed