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Xla Wt + ptpn11N308D, Langdon Y et al. (2012)

Experiment + Assay: Xla Wt + ptpn11N308D + NF40 (immunohistochemistry)
Background: Xla.Outbred
Manipulation Type Reagent Target Gene Stage Treatment Area
DNA injection Tg(ptpn11N308D) ptpn11 (Xla)
NF stage 1 embryo
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 40 Myh6 Ab2
Anatomical Phenotypes: abnormal heart looping, abnormal heart morphology, abnormally edematous pericardium
Human Disease Associations: Noonan syndrome
Source: Fig. 7 GI
Article: XB-ART-44762, PubMed