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XB-PHENO-25389

Xla Wt + pqbp1 MO, Iwasaki Y and Thomsen GH (2014)

Experiment + Assay: Xla Wt + pqbp1 MO + NF19 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection pqbp1 MO1 pqbp1 (Xla)
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 19  
Anatomical Phenotypes: abnormal neural fold morphology , decreased cell adhesion in neuroectoderm
Expression Phenotypes (3):
decreased amount snai2.L expression in neural crest
decreased amount snai2.L expression in neural plate border
decreased amount sox2.L expression in neural plate
Human Disease Associations: Renpenning syndrome
Source: Fig.3.D
Article: XB-ART-49433, PubMed