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XB-PHENO-25838

Xtr Wt + kmt5b MO + kmt5c MO (H1/H2KD), Angerilli A et al. (2023)

Experiment + Assay: Xtr Wt + kmt5b MO + kmt5c MO (H1/H2KD) + NF35/36 (in situ hybridization)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection kmt5c MO1 kmt5c
 NF stage 2 (2-cell) animal pole
morpholino injection kmt5b MO1 kmt5b
 NF stage 2 (2-cell) animal pole
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36 to NF stage 35 and 36  
Anatomical Phenotypes: abnormal embryo morphology , abnormal main body axis morphology , abnormal multiciliated cell morphology , abnormally decreased number of cilium in the ciliated cell
Expression Phenotypes (1):
absent tuba4b expression in multiciliated epidermal cell
Source: Fig. 5. A r4c2, B
Article: XB-ART-59747, PubMed