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Summary Expression Phenotypes Gene Literature (177) GO Terms (0) Nucleotides (44) Proteins (32) Interactants (264) Wiki
XB--985558

Papers associated with kcnh1



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Camguk/CASK enhances Ether-á-go-go potassium current by a phosphorylation-dependent mechanism., Marble DD, Hegle AP, Snyder ED, Dimitratos S, Bryant PJ, Wilson GF., J Neurosci. May 18, 2005; 25 (20): 4898-907.

Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine., Choi SY, Koh YS, Jo SH., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.

Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes., Kim CS, Son SJ, Kim HS, Kim YD, Lee KS, Jeon BH, Kim KJ, Park JK, Park JB., Acta Pharmacol Sin. May 1, 2005; 26 (5): 551-8.

Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels., Dupuis DS, Klaerke DA, Olesen SP., Basic Clin Pharmacol Toxicol. February 1, 2005; 96 (2): 123-30.

A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels., Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J., Am J Ther. January 1, 2005; 12 (4): 328-36.

Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels., Craven KB, Zagotta WN., J Gen Physiol. December 1, 2004; 124 (6): 663-77.                      

Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine., Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.

Gating charges in the activation and inactivation processes of the HERG channel., Zhang M, Liu J, Tseng GN., J Gen Physiol. December 1, 2004; 124 (6): 703-18.                    

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., Thomas D, Wu K, Wimmer AB, Zitron E, Hammerling BC, Kathöfer S, Lueck S, Bloehs R, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.

Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel., Silverman WR, Bannister JP, Papazian DM., Biophys J. November 1, 2004; 87 (5): 3110-21.

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel., Subbiah RN, Clarke CE, Smith DJ, Zhao J, Campbell TJ, Vandenberg JI., J Physiol. July 15, 2004; 558 (Pt 2): 417-31.

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels., Tsujimae K, Suzuki S, Yamada M, Kurachi Y., Eur J Pharmacol. June 16, 2004; 493 (1-3): 29-40.

Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels., Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF., Basic Clin Pharmacol Toxicol. May 1, 2004; 94 (5): 209-12.

Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents., Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH., Mol Pharmacol. May 1, 2004; 65 (5): 1120-9.

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.

Modification of Kv2.1 K+ currents by the silent Kv10 subunits., Vega-Saenz de Miera EC., Brain Res Mol Brain Res. April 7, 2004; 123 (1-2): 91-103.

Distribution and functional properties of human KCNH8 (Elk1) potassium channels., Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD., Am J Physiol Cell Physiol. December 1, 2003; 285 (6): C1356-66.

Gating currents associated with intramembrane charge displacement in HERG potassium channels., Piper DR, Varghese A, Sanguinetti MC, Tristani-Firouzi M., Proc Natl Acad Sci U S A. September 2, 2003; 100 (18): 10534-9.

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes., Liu J, Zhang M, Jiang M, Tseng GN., J Gen Physiol. June 1, 2003; 121 (6): 599-614.                                  

Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain., Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC., Mol Pharmacol. May 1, 2003; 63 (5): 1051-8.

BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1., Zhang M, Korolkova YV, Liu J, Jiang M, Grishin EV, Tseng GN., Biophys J. May 1, 2003; 84 (5): 3022-36.

Molecular characterization, functional expression, and developmental profile of an ether à-go-go K+ channel in the tobacco hornworm Manduca sexta., Keyser MR, Anson BD, Titus SA, Ganetzky B, Witten JL., J Neurobiol. April 1, 2003; 55 (1): 73-85.

Structural basis of two-stage voltage-dependent activation in K+ channels., Silverman WR, Roux B, Papazian DM., Proc Natl Acad Sci U S A. March 4, 2003; 100 (5): 2935-40.

C-terminal domains implicated in the functional surface expression of potassium channels., Jenke M, Sánchez A, Monje F, Stühmer W, Weseloh RM, Pardo LA., EMBO J. February 3, 2003; 22 (3): 395-403.

Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region., Shoeb F, Malykhina AP, Akbarali HI., J Biol Chem. January 24, 2003; 278 (4): 2503-14.

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels., Chen J, Seebohm G, Sanguinetti MC., Proc Natl Acad Sci U S A. September 17, 2002; 99 (19): 12461-6.

Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel., Schönherr R, Mannuzzu LM, Isacoff EY, Heinemann SH., Neuron. August 29, 2002; 35 (5): 935-49.

Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel., Wang Z, Wilson GF, Griffith LC., J Biol Chem. July 5, 2002; 277 (27): 24022-9.

Open channel block by KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] of the heterologously expressed human ether-a-go-go-related gene K+ channels., Park JB, Choe H, Lee YK, Ha KC, Rhee KS, Ko JK, Joo CU, Chae SW, Kwak YG., J Pharmacol Exp Ther. July 1, 2002; 302 (1): 314-9.

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block., Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC., J Biol Chem. June 28, 2002; 277 (26): 23587-95.

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels., Tristani-Firouzi M, Chen J, Sanguinetti MC., J Biol Chem. May 24, 2002; 277 (21): 18994-9000.

Functional distinction of human EAG1 and EAG2 potassium channels., Schönherr R, Gessner G, Löber K, Heinemann SH., FEBS Lett. March 13, 2002; 514 (2-3): 204-8.

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels., Thomas D, Gut B, Wendt-Nordahl G, Kiehn J., J Pharmacol Exp Ther. February 1, 2002; 300 (2): 543-8.

Mapping the receptor site for ergtoxin, a specific blocker of ERG channels., Pardo-López L, García-Valdés J, Gurrola GB, Robertson GA, Possani LD., FEBS Lett. January 2, 2002; 510 (1-2): 45-9.

Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels., Ficker E, Jarolimek W, Brown AM., Mol Pharmacol. December 1, 2001; 60 (6): 1343-8.

The S4-S5 linker couples voltage sensing and activation of pacemaker channels., Chen J, Mitcheson JS, Tristani-Firouzi M, Lin M, Sanguinetti MC., Proc Natl Acad Sci U S A. September 25, 2001; 98 (20): 11277-82.

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872., Thomas D, Wendt-Nordahl G, Röckl K, Ficker E, Brown AM, Kiehn J., J Pharmacol Exp Ther. May 1, 2001; 297 (2): 753-61.

Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes., Li BX, Yang BF, Zhou J, Xu CQ, Li YR., Acta Pharmacol Sin. February 1, 2001; 22 (2): 125-31.

Antiarrhythmic drug carvedilol inhibits HERG potassium channels., Karle CA, Kreye VA, Thomas D, Röckl K, Kathöfer S, Zhang W, Kiehn J., Cardiovasc Res. February 1, 2001; 49 (2): 361-70.

Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3., Silverman WR, Tang CY, Mock AF, Huh KB, Papazian DM., J Gen Physiol. November 1, 2000; 116 (5): 663-78.                  

Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression., Chen ML, Hoshi T, Wu CF., Biophys J. September 1, 2000; 79 (3): 1358-68.

Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating., Viloria CG, Barros F, Giráldez T, Gómez-Varela D, de la Peña P., Biophys J. July 1, 2000; 79 (1): 231-46.

Altered gating of HERG potassium channels by cobalt and lanthanum., Sanchez-Chapula JA, Sanguinetti MC., Pflugers Arch. June 1, 2000; 440 (2): 264-74.

Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects., Kreutner W, Hey JA, Chiu P, Barnett A., Arzneimittelforschung. May 1, 2000; 50 (5): 441-8.

Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline., Jo SH, Youm JB, Lee CO, Lee CO, Earm YE, Ho WK., Br J Pharmacol. April 1, 2000; 129 (7): 1474-80.

Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à-Go-Go potassium channels., Tang CY, Bezanilla F, Papazian DM., J Gen Physiol. March 1, 2000; 115 (3): 319-38.                            

Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex., Saganich MJ, Vega-Saenz de Miera E, Nadal MS, Baker H, Coetzee WA, Rudy B., J Neurosci. December 15, 1999; 19 (24): 10789-802.

Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-à-go-go channel., Piros ET, Shen L, Huang XY., J Biol Chem. November 19, 1999; 274 (47): 33677-83.

Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2., Nakajima T, Furukawa T, Hirano Y, Tanaka T, Sakurada H, Takahashi T, Nagai R, Itoh T, Katayama Y, Nakamura Y, Hiraoka M., Cardiovasc Res. November 1, 1999; 44 (2): 283-93.

Proton and zinc effects on HERG currents., Anumonwo JM, Horta J, Delmar M, Taffet SM, Jalife J., Biophys J. July 1, 1999; 77 (1): 282-98.

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