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Summary Expression Phenotypes Gene Literature (242) GO Terms (8) Nucleotides (225) Proteins (62) Interactants (1337) Wiki
XB--482929

Papers associated with smad2



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Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding., Nagarajan RP, Liu J, Chen Y., J Biol Chem. October 29, 1999; 274 (44): 31229-35.

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes., Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P, Hill CS., Dev Biol. October 15, 1999; 214 (2): 354-69.

Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo., Müller F, Blader P, Rastegar S, Fischer N, Knöchel W, Strähle U., Mech Dev. October 1, 1999; 88 (1): 73-88.  

The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis., Yeo CY, Chen X, Whitman M., J Biol Chem. September 10, 1999; 274 (37): 26584-90.

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation., Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH., Nature. August 12, 1999; 400 (6745): 687-93.

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes., Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, Nelles L, Wuytens G, Su MT, Bodmer R, Smith JC, Huylebroeck D., J Biol Chem. July 16, 1999; 274 (29): 20489-98.                

A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation., Shimizu K, Gurdon JB., Proc Natl Acad Sci U S A. June 8, 1999; 96 (12): 6791-6.

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals., Christian JL, Nakayama T., Bioessays. May 1, 1999; 21 (5): 382-90.

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties., Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E., J Biol Chem. April 23, 1999; 274 (17): 12163-70.                

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling., Gritsman K, Zhang J, Cheng S, Heckscher E, Talbot WS, Schier AF., Cell. April 2, 1999; 97 (1): 121-32.

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus., Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH., Dev Biol. March 15, 1999; 207 (2): 364-79.

A molecular basis for Smad specificity., Lagna G, Hemmati-Brivanlou A., Dev Dyn. March 1, 1999; 214 (3): 269-77.

Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals., Das P, Inoue H, Baker JC, Beppu H, Kawabata M, Harland RM, Miyazono K, Padgett RW., Genes Cells. February 1, 1999; 4 (2): 123-34.  

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3., Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K., J Biol Chem. January 8, 1999; 274 (2): 703-9.

FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals., Liu B, Dou CL, Prabhu L, Lai E., Mol Cell Biol. January 1, 1999; 19 (1): 424-30.

The embryonic expression of the tissue-specific transcription factor HNF1alpha in Xenopus: rapid activation by HNF4 and delayed induction by mesoderm inducers., Nastos A, Pogge von Strandmann E, Weber H, Ryffel GU., Nucleic Acids Res. December 15, 1998; 26 (24): 5602-8.

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor., Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL., Cell. December 11, 1998; 95 (6): 779-91.

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis., Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M., Mech Dev. December 1, 1998; 79 (1-2): 17-27.        

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2., Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL., J Biol Chem. October 2, 1998; 273 (40): 25628-36.

Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors., Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P., J Biol Chem. September 25, 1998; 273 (39): 25364-70.        

Smad3 mutant mice develop metastatic colorectal cancer., Zhu Y, Richardson JA, Parada LF, Graff JM., Cell. September 18, 1998; 94 (6): 703-14.

Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos., Bhushan A, Chen Y, Vale W., Dev Biol. August 15, 1998; 200 (2): 260-8.              

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2., Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9378-83.

Characterization of human FAST-1, a TGF beta and activin signal transducer., Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B., Mol Cell. July 1, 1998; 2 (1): 121-7.

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2., Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L., Mol Cell. July 1, 1998; 2 (1): 109-20.

Smad2 role in mesoderm formation, left-right patterning and craniofacial development., Nomura M, Li E., Nature. June 25, 1998; 393 (6687): 786-90.

Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer., Casellas R, Brivanlou AH., Dev Biol. June 1, 1998; 198 (1): 1-12.                

Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression., Crease DJ, Dyson S, Gurdon JB., Proc Natl Acad Sci U S A. April 14, 1998; 95 (8): 4398-403.

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities., Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM., Mol Cell. April 1, 1998; 1 (5): 673-83.                  

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line., Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K., Genes Cells. February 1, 1998; 3 (2): 125-34.

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation., Yokota C, Takahashi S, Eisaki A, Asashima M, Akhter S, Muramatsu T, Kadomatsu K., J Biochem. February 1, 1998; 123 (2): 339-46.

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor., Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A., Genes Dev. January 15, 1998; 12 (2): 186-97.          

XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos., Howell M, Hill CS., EMBO J. December 15, 1997; 16 (24): 7411-21.

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes., Liu F, Pouponnot C, Massagué J., Genes Dev. December 1, 1997; 11 (23): 3157-67.

Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads., Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW., Development. November 1, 1997; 124 (22): 4467-80.

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P., Nature. October 9, 1997; 389 (6651): 631-5.

Smad4 and FAST-1 in the assembly of activin-responsive factor., Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M., Nature. September 4, 1997; 389 (6646): 85-9.

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4., Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P., EMBO J. September 1, 1997; 16 (17): 5353-62.

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4., Hata A, Lo RS, Wotton D, Lagna G, Massagué J., Nature. July 3, 1997; 388 (6637): 82-7.

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function., Zhang Y, Musci T, Derynck R., Curr Biol. April 1, 1997; 7 (4): 270-6.

Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway., Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P., J Biol Chem. January 31, 1997; 272 (5): 2896-900.

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways., Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J., Nature. October 31, 1996; 383 (6603): 832-6.

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