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Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. , Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI , Swartz KJ., Elife. January 6, 2015; 4 e06774.
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission. , Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S., BMC Biol. October 14, 2014; 12 84.
Intersubunit conformational changes mediate epithelial sodium channel gating. , Collier DM, Tomkovicz VR, Peterson ZJ, Benson CJ, Snyder PM ., J Gen Physiol. October 1, 2014; 144 (4): 337-48.
Ion conduction and selectivity in acid-sensing ion channel 1. , Yang L, Palmer LG., J Gen Physiol. September 1, 2014; 144 (3): 245-55.
Acid-sensing ion channel ( ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. , Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH., Proc Natl Acad Sci U S A. June 3, 2014; 111 (22): 8281-6.
Protonation controls ASIC1a activity via coordinated movements in multiple domains. , Bonifacio G, Lelli CI, Kellenberger S., J Gen Physiol. January 1, 2014; 143 (1): 105-18.
The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment. , Schmidt A, Lenzig P, Oslender-Bujotzek A, Kusch J, Lucas SD, Gründer S, Wiemuth D., PLoS One. January 1, 2014; 9 (10): e111549.
Independent contribution of extracellular proton binding sites to ASIC1a activation. , Krauson AJ, Rued AC, Carattino MD., J Biol Chem. November 29, 2013; 288 (48): 34375-83.
Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation. , Frey EN, Pavlovicz RE, Wegman CJ, Li C, Askwith CC., PLoS One. August 12, 2013; 8 (8): e71733.
Gating transitions in the palm domain of ASIC1a. , Della Vecchia MC, Rued AC, Carattino MD., J Biol Chem. February 22, 2013; 288 (8): 5487-95.
Impact of recovery from desensitization on acid-sensing ion channel-1a ( ASIC1a) current and response to high frequency stimulation. , Li T , Yang Y , Canessa CM., J Biol Chem. November 23, 2012; 287 (48): 40680-9.
Black mamba venom peptides target acid-sensing ion channels to abolish pain. , Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay AS, Debayle D, Friend V, Alloui A, Lazdunski M, Lingueglia E., Nature. October 25, 2012; 490 (7421): 552-5.
Subtype-specific modulation of acid-sensing ion channel ( ASIC) function by 2-guanidine-4-methylquinazoline. , Alijevic O, Kellenberger S., J Biol Chem. October 19, 2012; 287 (43): 36059-70.
High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra. , Dürrnagel S, Falkenburger BH, Gründer S., J Gen Physiol. October 1, 2012; 140 (4): 391-402.
Lignan from thyme possesses inhibitory effect on ASIC3 channel current. , Dubinnyi MA, Osmakov DI, Koshelev SG, Kozlov SA, Andreev YA, Zakaryan NA, Dyachenko IA, Bondarenko DA, Arseniev AS, Grishin EV., J Biol Chem. September 21, 2012; 287 (39): 32993-3000.
Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity. , Carattino MD, Della Vecchia MC., J Biol Chem. April 13, 2012; 287 (16): 12927-34.
N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling. , Jing L, Chu XP, Jiang YQ, Collier DM, Wang B, Jiang Q, Snyder PM , Zha XM., J Neurosci. March 21, 2012; 32 (12): 4080-91.
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. , Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D., Nature. November 16, 2011; 479 (7373): 410-4.
Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors. , Santos-Torres J, Ślimak MA, Auer S, Ibañez-Tallon I., J Physiol. November 1, 2011; 589 (Pt 21): 5109-23.
The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1. , Springauf A, Bresenitz P, Gründer S., J Biol Chem. July 8, 2011; 286 (27): 24374-84.
Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. , Sherwood TW, Lee KG, Gormley MG, Askwith CC., J Neurosci. June 29, 2011; 31 (26): 9723-34.
Insights into the mechanism of pore opening of acid-sensing ion channel 1a. , Tolino LA, Okumura S, Kashlan OB, Carattino MD., J Biol Chem. May 6, 2011; 286 (18): 16297-307.
Base of the thumb domain modulates epithelial sodium channel gating. , Shi S, Ghosh DD, Okumura S, Carattino MD, Kashlan OB, Sheng S, Kleyman TR., J Biol Chem. April 29, 2011; 286 (17): 14753-61.
Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis. , Edelheit O, Hanukoglu I, Dascal N , Hanukoglu A., Am J Physiol Renal Physiol. April 1, 2011; 300 (4): F887-97.
Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block. , Li T , Yang Y , Canessa CM., J Gen Physiol. March 1, 2011; 137 (3): 289-97.
Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1. , Li T , Yang Y , Canessa CM., Nat Commun. January 1, 2011; 2 399.
Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. , Hoagland EN, Sherwood TW, Lee KG, Walker CJ, Askwith CC., J Biol Chem. December 31, 2010; 285 (53): 41852-62.
Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1. , Li T , Yang Y , Canessa CM., J Biol Chem. October 8, 2010; 285 (41): 31285-91.
Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase. , Clark EB, Jovov B, Rooj AK, Fuller CM, Benos DJ., J Biol Chem. August 27, 2010; 285 (35): 27130-43.
Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation. , Li T , Yang Y , Canessa CM., J Biol Chem. July 16, 2010; 285 (29): 22706-12.
Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel. , Li T , Yang Y , Canessa CM., Am J Physiol Cell Physiol. July 1, 2010; 299 (1): C66-73.
Diarylamidines: high potency inhibitors of acid-sensing ion channels. , Chen X, Qiu L, Li M, Dürrnagel S, Orser BA, Xiong ZG, MacDonald JF., Neuropharmacology. June 1, 2010; 58 (7): 1045-53.
The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function. , Bargeton B, Kellenberger S., J Biol Chem. April 30, 2010; 285 (18): 13816-26.
The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. , Ben-Shahar Y, Lu B , Collier DM, Snyder PM , Schnizler M, Welsh MJ., PLoS One. February 2, 2010; 5 (2): e9395.
Conformational changes associated with proton-dependent gating of ASIC1a. , Passero CJ, Okumura S, Carattino MD., J Biol Chem. December 25, 2009; 284 (52): 36473-36481.
Structural elements for the generation of sustained currents by the acid pain sensor ASIC3. , Salinas M, Lazdunski M, Lingueglia E., J Biol Chem. November 13, 2009; 284 (46): 31851-9.
Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. , Sherwood TW, Askwith CC., J Neurosci. November 11, 2009; 29 (45): 14371-80.
Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel. , Wang Y, Bianchi L., Biochemistry. October 27, 2009; 48 (42): 10005-13.
Extracellular chloride regulates the epithelial sodium channel. , Collier DM, Snyder PM ., J Biol Chem. October 23, 2009; 284 (43): 29320-5.
Identification of protein domains that control proton and calcium sensitivity of ASIC1a. , Sherwood T, Franke R, Conneely S, Joyner J, Arumugan P, Askwith C., J Biol Chem. October 9, 2009; 284 (41): 27899-907.
Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. , Zha XM, Wang R , Collier DM, Snyder PM , Wemmie JA, Welsh MJ., Proc Natl Acad Sci U S A. March 3, 2009; 106 (9): 3573-8.
Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels. , Li T , Yang Y , Canessa CM., J Biol Chem. February 13, 2009; 284 (7): 4689-94.
Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function. , Bashari E, Qadri YJ, Zhou ZH, Kapoor N, Anderson SJ, Meltzer RH, Fuller CM, Benos DJ., Am J Physiol Cell Physiol. February 1, 2009; 296 (2): C372-84.
Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel ( ASIC) 1a and ASIC1b. , Kadurin I, Golubovic A, Leisle L, Schindelin H, Gründer S., Biochem J. June 15, 2008; 412 (3): 469-75.
Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. , Sherwood TW, Askwith CC., J Biol Chem. January 25, 2008; 283 (4): 1818-30.
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a. , Paukert M, Chen X, Polleichtner G, Schindelin H, Gründer S., J Biol Chem. January 4, 2008; 283 (1): 572-581.
Nafamostat mesilate reversibly blocks acid-sensing ion channel currents. , Ugawa S, Ishida Y, Ueda T, Inoue K, Nagao M, Shimada S., Biochem Biophys Res Commun. November 9, 2007; 363 (1): 203-8.
Zebrafish acid-sensing ion channel ( ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+. , Chen X, Polleichtner G, Kadurin I, Gründer S., J Biol Chem. October 19, 2007; 282 (42): 30406-13.
Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel ( ASIC) 1a. , Chen X, Gründer S., J Physiol. March 15, 2007; 579 (Pt 3): 657-70.
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium. , Chen X, Paukert M, Kadurin I, Pusch M, Gründer S., Neuropharmacology. June 1, 2006; 50 (8): 964-74.