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Summary Expression Phenotypes Gene Literature (303) GO Terms (6) Nucleotides (87) Proteins (45) Interactants (179) Wiki
XB-GENEPAGE-1004370

Papers associated with kcnj3



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Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors., Takemura Y, Sudo Y, Saeki T, Kurata S, Suzuki T, Mori T, Uezono Y., J Pharmacol Sci. July 1, 2022; 149 (3): 85-92.


AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels., An D, Pinheiro-Junior EL, Béress L, Gladkikh I, Leychenko E, Undheim EAB, Peigneur S, Tytgat J., Mar Drugs. February 15, 2022; 20 (2):


A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel., Chen IS, Eldstrom J, Fedida D, Kubo Y., J Physiol. January 1, 2022; 600 (3): 603-622.


A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5)., Shalomov B, Handklo-Jamal R, Reddy HP, Theodor N, Bera AK, Dascal N., J Physiol. January 1, 2022; 600 (6): 1419-1437.


The activity of the serotonergic 5-HT1A receptor is modulated by voltage and sodium levels., Tauber M, Ben Chaim Y., J Biol Chem. January 1, 2022; 298 (6): 101978.              


WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels., An D, Peigneur S, Tytgat J., Biomedicines. April 28, 2021; 9 (5):               


Identification of a unique endoplasmic retention motif in the Xenopus GIRK5 channel and its contribution to oocyte maturation., Rangel-Garcia CI, Salvador C, Chavez-Garcia K, Diaz-Bello B, Lopez-Gonzalez Z, Vazquez-Cruz L, Angel Vazquez-Martinez J, Ortiz-Navarrete V, Riveros-Rosas H, Escobar LI., FEBS Open Bio. January 1, 2021; 11 (4): 1093-1108.            


Hydrogen Sulfide Impairs Meiosis Resumption in Xenopuslaevis Oocytes., Gelaude A, Slaby S, Cailliau K, Marin M, Lescuyer-Rousseau A, Molinaro C, Nevoral J, Kučerová-Chrpová V, Sedmikova M, Petr J, Martoriati A, Bodart JF., Cells. January 1, 2020; 9 (1):                   


Sodium ions allosterically modulate the M2 muscarinic receptor., Friedman S, Tauber M, Ben-Chaim Y., Sci Rep. January 1, 2020; 10 (1): 11177.          


Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism., Ågren R, Zeberg H, Stępniewski TM, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K., ACS Chem Neurosci. January 1, 2020; 11 (19): 3130-3143.            


A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors., Berlin S, Artzy E, Handklo-Jamal R, Kahanovitch U, Parnas H, Dascal N, Yakubovich D., Front Pharmacol. January 1, 2020; 11 1216.                              


Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors., Ågren R, Sahlholm K., Front Pharmacol. January 1, 2020; 11 581151.    


The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents., Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA., J Biol Chem. January 1, 2020; 295 (11): 3614-3634.


Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K+ Channel) Channel Function., Kuß J, Stallmeyer B, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz MC, Schulze-Bahr E., Circ Genom Precis Med. January 1, 2019; 12 (1): e002238.


Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner., Tabak G, Keren-Raifman T, Kahanovitch U, Dascal N., Sci Rep. January 1, 2019; 9 (1): 508.                    


A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor., Hauwert NJ, Mocking TAM, Da Costa Pereira D, Lion K, Huppelschoten Y, Vischer HF, De Esch IJP, Wijtmans M, Leurs R., Angew Chem Int Ed Engl. January 1, 2019; 58 (14): 4531-4535.        


Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y., Br J Pharmacol. January 1, 2019; 176 (17): 3161-3179.


The coupling of the M2 muscarinic receptor to its G protein is voltage dependent., Ben-Chaim Y, Broide C, Parnas H., PLoS One. January 1, 2019; 14 (10): e0224367.          


Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation., Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S., Circulation. January 1, 2019; 139 (18): 2157-2169.


Point mutation of a conserved aspartate, D69, in the muscarinic M 2  receptor does not modify voltage-sensitive agonist potency., Ågren R, Sahlholm K, Nilsson J, Århem P., Biochem Biophys Res Commun. January 1, 2018; 496 (1): 101-104.  


The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation., Ågren R, Århem P, Nilsson J, Sahlholm K., Int J Neuropsychopharmacol. January 1, 2018; 21 (12): 1102-1108.    


Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation., Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y., J Physiol. September 1, 2017; 595 (17): 5895-5912.


A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction., Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E., Circ Res. May 12, 2017; 120 (10): e33-e44.


Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus., Bukiya AN, Durdagi S, Noskov S, Rosenhouse-Dantsker A., J Biol Chem. January 1, 2017; 292 (15): 6135-6147.


Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity., Chen IS, Furutani K, Kurachi Y., Sci Rep. January 1, 2017; 7 (1): 6110.          


Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors., Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY., Neuron. October 5, 2016; 92 (1): 143-159.                                  


Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells., Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park G, Vysotskaya Z, Narahari A, Sealfon SC, Gonzalez-Maeso J, Logothetis DE., Pflugers Arch. May 1, 2016; 468 (5): 775-93.


Mitragynine and its potential blocking effects on specific cardiac potassium channels., Tay YL, Teah YF, Chong YM, Jamil MFA, Kollert S, Adenan MI, Wahab HA, Döring F, Wischmeyer E, Tan ML., Toxicol Appl Pharmacol. January 1, 2016; 305 22-39.


GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin., Hablitz LM, Molzof HE, Abrahamsson KE, Cooper JM, Prosser RA, Gamble KL., J Neurosci. November 11, 2015; 35 (45): 14957-65.


A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ., Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N., PLoS Comput Biol. November 1, 2015; 11 (11): e1004598.                  


Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1., Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N., J Physiol. December 15, 2014; 592 (24): 5373-90.


Dual regulation of G proteins and the G-protein-activated K+ channels by lithium., Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N., Proc Natl Acad Sci U S A. April 1, 2014; 111 (13): 5018-23.


RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents., Chen IS, Furutani K, Inanobe A, Kurachi Y., J Physiol. March 15, 2014; 592 (6): 1237-48.            


Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes., Kienitz MC, Mintert-Jancke E, Hertel F, Pott L., Cell Signal. February 24, 2014; 26 (6): 1182-1192.


G protein-coupled receptor signaling to Kir channels in Xenopus oocytes., Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE., Curr Pharm Biotechnol. January 1, 2014; 15 (10): 987-95.


Baclofen and other GABAB receptor agents are allosteric modulators of the CXCL12 chemokine receptor CXCR4., Guyon A, Kussrow A, Olmsted IR, Sandoz G, Bornhop DJ, Nahon JL., J Neurosci. July 10, 2013; 33 (28): 11643-54.


Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase., Treiber F, Rosker C, Keren-Raifman T, Steinecker B, Gorischek A, Dascal N, Schreibmayer W., Biochim Biophys Acta. April 1, 2013; 1828 (4): 1214-21.              


The polarization of the G-protein activated potassium channel GIRK5 to the vegetal pole of Xenopus laevis oocytes is driven by a di-leucine motif., Díaz-Bello B, Rangel-García CI, Salvador C, Carrisoza-Gaytán R, Escobar LI., PLoS One. January 1, 2013; 8 (5): e64096.                


Voltage affects the dissociation rate constant of the m2 muscarinic receptor., Ben Chaim Y, Bochnik S, Parnas I, Parnas H., PLoS One. January 1, 2013; 8 (9): e74354.          


Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors., Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P., Biochim Biophys Acta. December 1, 2012; 1818 (12): 3081-9.


RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo., Chuang HH, Chuang AY., Sci Signal. February 21, 2012; 5 (212): ra15.


Engineering of an artificial light-modulated potassium channel., Caro LN, Moreau CJ, Estrada-Mondragón A, Ernst OP, Vivaudou M., PLoS One. January 1, 2012; 7 (8): e43766.          


The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes., Sahlholm K., Biochem Biophys Res Commun. November 25, 2011; 415 (3): 509-14.


The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D₂ and serotonin 5-HT₁A receptors., Heusler P, Bruins Slot L, Tourette A, Tardif S, Cussac D., Eur J Pharmacol. November 1, 2011; 669 (1-3): 51-8.


Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands., Sahlholm K, Barchad-Avitzur O, Marcellino D, Gómez-Soler M, Fuxe K, Ciruela F, Arhem P., Neuropharmacology. October 1, 2011; 61 (5-6): 937-49.


Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium., Whorton MR, MacKinnon R., Cell. September 30, 2011; 147 (1): 199-208.


Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits., Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N., J Biol Chem. September 23, 2011; 286 (38): 33223-35.


Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents., Loscalzo LM, Yow TT, Wasowski C, Chebib M, Marder M., Pharmacol Biochem Behav. September 1, 2011; 99 (3): 333-41.


β2-Adrenergic ion-channel coupled receptors as conformational motion detectors., Caro LN, Moreau CJ, Revilloud J, Vivaudou M., PLoS One. March 2, 2011; 6 (3): e18226.            


Inhibition of g protein-activated inwardly rectifying k channels by phencyclidine., Kobayashi T, Nishizawa D, Ikeda K., Curr Neuropharmacol. March 1, 2011; 9 (1): 244-6.    

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