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Summary Expression Phenotypes Gene Literature (85) GO Terms (7) Nucleotides (591) Proteins (41) Interactants (719) Wiki
XB-GENEPAGE-1032977

Papers associated with cdknx



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Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107., Smith HC, Spector DL, Woodcock CL, Ochs RL, Bhorjee J., J Cell Biol. August 1, 1985; 101 (2): 560-7.

Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1., Su JY, Rempel RE, Erikson E, Maller JL., Proc Natl Acad Sci U S A. October 24, 1995; 92 (22): 10187-91.

Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases., Shou W, Dunphy WG., Mol Biol Cell. March 1, 1996; 7 (3): 457-69.

A role for cyclin E/Cdk2 in the timing of the midblastula transition in Xenopus embryos., Hartley RS, Sible JC, Lewellyn AL, Maller JL., Dev Biol. August 15, 1997; 188 (2): 312-21.

Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle., Yew PR, Kirschner MW., Science. September 12, 1997; 277 (5332): 1672-6.

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning., Gawantka V, Pollet N, Delius H, Vingron M, Pfister R, Nitsch R, Blumenstock C, Niehrs C., Mech Dev. October 1, 1998; 77 (2): 95-141.                                                            

p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina., Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA., Cell. November 24, 1999; 99 (5): 499-510.              

Distinct effects of XBF-1 in regulating the cell cycle inhibitor p27(XIC1) and imparting a neural fate., Hardcastle Z, Papalopulu N., Development. March 1, 2000; 127 (6): 1303-14.                  

Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1., Swanson C, Ross J, Jackson PK., Proc Natl Acad Sci U S A. July 5, 2000; 97 (14): 7796-801.

Cell cycle transitions in early Xenopus development., Maller JL, Gross SD, Schwab MS, Finkielstein CV, Taieb FE, Qian YW., Novartis Found Symp. January 1, 2001; 237 58-73; discussion 73-8.

Regulation of nuclear transport and degradation of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1., Chuang LC, Yew PR., J Biol Chem. January 12, 2001; 276 (2): 1610-7.

The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage., Finkielstein CV, Lewellyn AL, Maller JL., Proc Natl Acad Sci U S A. January 30, 2001; 98 (3): 1006-11.            

Becoming glial in the neural retina., Vetter ML, Moore KB., Dev Dyn. June 1, 2001; 221 (2): 146-53.

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication., Furstenthal L, Swanson C, Kaiser BK, Eldridge AG, Jackson PK., Nat Cell Biol. August 1, 2001; 3 (8): 715-22.

Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina., Ohnuma S, Hopper S, Wang KC, Philpott A, Harris WA., Development. May 1, 2002; 129 (10): 2435-46.            

Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication., You Z, Harvey K, Kong L, Newport J., Genes Dev. May 15, 2002; 16 (10): 1182-94.

The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus., Vernon AE, Devine C, Philpott A., Development. January 1, 2003; 130 (1): 85-92.          

A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus., Vernon AE, Philpott A., Development. January 1, 2003; 130 (1): 71-83.            

Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis., Carruthers S, Mason J, Papalopulu N., Mech Dev. May 1, 2003; 120 (5): 607-16.            

A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus laevis embryos., Ciliberto A, Petrus MJ, Tyson JJ, Sible JC., Biophys Chem. July 1, 2003; 104 (3): 573-89.

Xrx1 controls proliferation and neurogenesis in Xenopus anterior neural plate., Andreazzoli M, Gestri G, Cremisi F, Casarosa S, Dawid IB, Barsacchi G., Development. November 1, 2003; 130 (21): 5143-54.              

Regulation of vertebrate eye development by Rx genes., Bailey TJ, El-Hodiri H, Zhang L, Shah R, Mathers PH, Jamrich M., Int J Dev Biol. January 1, 2004; 48 (8-9): 761-70.    

Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division., Kaiser BK, Nachury MV, Gardner BE, Jackson PK., BMC Cell Biol. July 13, 2004; 5 27.        

Identification of Xenopus cyclin-dependent kinase inhibitors, p16Xic2 and p17Xic3., Daniels M, Dhokia V, Richard-Parpaillon L, Ohnuma S., Gene. November 10, 2004; 342 (1): 41-7.                

Role of TSC-22 during early embryogenesis in Xenopus laevis., Hashiguchi A, Okabayashi K, Asashima M., Dev Growth Differ. December 1, 2004; 46 (6): 535-44.                

Xenopus aristaless-related homeobox (xARX) gene product functions as both a transcriptional activator and repressor in forebrain development., Seufert DW, Prescott NL, El-Hodiri HM., Dev Dyn. February 1, 2005; 232 (2): 313-24.                  

Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein., Liu KJ, Liu KJ, Harland RM., Development. April 1, 2005; 132 (7): 1511-23.                

Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression., Gestri G, Carl M, Appolloni I, Wilson SW, Barsacchi G, Andreazzoli M., Development. May 1, 2005; 132 (10): 2401-13.              

Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching., Chuang LC, Yew PR., J Biol Chem. October 21, 2005; 280 (42): 35299-309.

The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis., Chuang LC, Zhu XN, Herrera CR, Tseng HM, Pfleger CM, Block K, Yew PR., J Biol Chem. October 21, 2005; 280 (42): 35290-8.

Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2., Lin HR, Chuang LC, Boix-Perales H, Philpott A, Yew PR., Cell Cycle. February 1, 2006; 5 (3): 304-14.

Mxi1 is essential for neurogenesis in Xenopus and acts by bridging the pan-neural and proneural genes., Klisch TJ, Souopgui J, Juergens K, Rust B, Pieler T, Henningfeld KA., Dev Biol. April 15, 2006; 292 (2): 470-85.                

Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons., Vernon AE, Movassagh M, Horan I, Wise H, Ohnuma S, Philpott A., EMBO Rep. June 1, 2006; 7 (6): 643-8.

The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle., Boix-Perales H, Horan I, Wise H, Lin HR, Chuang LC, Yew PR, Philpott A., Neural Dev. March 15, 2007; 2 27.                      

TSC-box is essential for the nuclear localization and antiproliferative effect of XTSC-22., Hashiguchi A, Hitachi K, Inui M, Okabayashi K, Asashima M., Dev Growth Differ. April 1, 2007; 49 (3): 197-204.

Xenopus hairy2 functions in neural crest formation by maintaining cells in a mitotic and undifferentiated state., Nagatomo K, Hashimoto C., Dev Dyn. June 1, 2007; 236 (6): 1475-83.          

Alterations of rx1 and pax6 expression levels at neural plate stages differentially affect the production of retinal cell types and maintenance of retinal stem cell qualities., Zaghloul NA, Moody SA., Dev Biol. June 1, 2007; 306 (1): 222-40.                      

Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis., Wroble BN, Finkielstein CV, Sible JC., BMC Dev Biol. October 25, 2007; 7 119.          

Chk1 is activated at the midblastula transition in Xenopus laevis embryos independently of DNA content and the cyclin E/Cdk2 developmental timer., Adjerid N, Wroble BN, Sible JC., Cell Cycle. April 15, 2008; 7 (8): 1112-6.

A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes., Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE., Dev Biol. May 1, 2008; 317 (1): 380-8.  

Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1., Movassagh M, Philpott A., Cardiovasc Res. August 1, 2008; 79 (3): 436-47.                                

Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion., Schlosser G, Awtry T, Brugmann SA, Jensen ED, Neilson K, Ruan G, Stammler A, Voelker D, Yan B, Zhang C, Klymkowsky MW, Moody SA., Dev Biol. August 1, 2008; 320 (1): 199-214.                  

Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1., Mochizuki T, Bilitou A, Waters CT, Hussain K, Zollo M, Ohnuma S., Neural Dev. January 5, 2009; 4 1.                      

Xhairy2 functions in Xenopus lens development by regulating p27(xic1) expression., Murato Y, Hashimoto C., Dev Dyn. September 1, 2009; 238 (9): 2179-92.              

Normal levels of p27 are necessary for somite segmentation and determining pronephric organ size., Naylor RW, Collins RJ, Philpott A, Jones EA., Organogenesis. October 1, 2009; 5 (4): 201-10.                                          

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality., Slavic K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S., Mol Microbiol. March 1, 2010; 75 (6): 1402-13.              

The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA., Kim DH, Budhavarapu VN, Herrera CR, Nam HW, Kim YS, Yew PR., Mol Cell Biol. September 1, 2010; 30 (17): 4120-33.

Sumoylation controls retinal progenitor proliferation by repressing cell cycle exit in Xenopus laevis., Terada K, Furukawa T., Dev Biol. November 1, 2010; 347 (1): 180-94.                                                  

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis., Michishita M, Morimoto A, Ishii T, Komori H, Shiomi Y, Higuchi Y, Nishitani H., Genes Cells. January 1, 2011; 16 (1): 12-22.        

Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone., Gee ST, Milgram SL, Kramer KL, Conlon FL, Moody SA., PLoS One. January 1, 2011; 6 (6): e20309.                  

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