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Summary Expression Phenotypes Gene Literature (33) GO Terms (32) Nucleotides (88) Proteins (41) Interactants (413) Wiki
XB--478209

Papers associated with fzd4



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Modeling endoderm development and disease in Xenopus., Edwards NA, Zorn AM., Curr Top Dev Biol. January 1, 2021; 145 61-90.

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G., J Biol Chem. June 26, 2020; 295 (26): 8759-8774.          

Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis., Piprek RP, Damulewicz M, Tassan JP, Kloc M, Kubiak JZ., Dev Genes Evol. May 1, 2019; 229 (2-3): 53-72.        

RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus., Janesick A, Tang W, Shioda T, Blumberg B., Development. September 17, 2018; 145 (18):                           

Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis., Gere-Becker MB, Pommerenke C, Lingner T, Pieler T., Development. June 8, 2018; 145 (12):                                   

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled., Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G., Cell Signal. October 1, 2017; 38 85-96.

TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling., Lai MB, Zhang C, Shi J, Johnson V, Khandan L, McVey J, Klymkowsky MW, Chen Z, Junge HJ., Cell Rep. June 27, 2017; 19 (13): 2809-2822.  

Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling., Hamilton PW, Sun Y, Henry JJ., Exp Eye Res. April 1, 2016; 145 206-215.          

GATA2 regulates Wnt signaling to promote primitive red blood cell fate., Mimoto MS, Kwon S, Green YS, Goldman D, Christian JL., Dev Biol. November 1, 2015; 407 (1): 1-11.                          

The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway., Luehders K, Sasai N, Davaapil H, Kurosawa-Yoshida M, Hiura H, Brah T, Ohnuma S., Development. October 1, 2015; 142 (19): 3351-61.                              

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan., Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY., Elife. July 9, 2015; 4                               

The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity., Abbruzzese G, Gorny AK, Kaufmann LT, Cousin H, Kleino I, Steinbeisser H, Alfandari D, Alfandari D., J Cell Sci. March 15, 2015; 128 (6): 1139-49.

A Molecular atlas of Xenopus respiratory system development., Rankin SA, Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Vleminckx K, Wert SE, Zorn AM., Dev Dyn. January 1, 2015; 244 (1): 69-85.                    

Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character., Fish MB, Nakayama T, Fisher M, Hirsch N, Cox A, Reeder R, Carruthers S, Hall A, Stemple DL, Grainger RM., Dev Biol. November 15, 2014; 395 (2): 317-330.                  

A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling., Gorny AK, Kaufmann LT, Swain RK, Steinbeisser H., Cell Commun Signal. November 19, 2013; 11 89.      

β-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements., Kim GH, Park EC, Lee H, Lee H, Na HJ, Choi SC, Han JK., Biochem Biophys Res Commun. May 31, 2013; 435 (2): 182-7.                  

Multi-functional norrin is a ligand for the LGR4 receptor., Deng C, Reddy P, Cheng Y, Luo CW, Hsiao CL, Hsueh AJ., J Cell Sci. May 1, 2013; 126 (Pt 9): 2060-8.                                  

An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy., Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw PX, He X, Yang Z., J Biol Chem. March 25, 2011; 286 (12): 10210-5.

Expression of Wnt signaling components during Xenopus pronephros development., Zhang B, Tran U, Wessely O., PLoS One. January 1, 2011; 6 (10): e26533.                      

Macrophage Wnt7b is critical for kidney repair and regeneration., Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS., Proc Natl Acad Sci U S A. March 2, 2010; 107 (9): 4194-9.      

The opposing roles of Wnt-5a in cancer., McDonald SL, Silver A., Br J Cancer. July 21, 2009; 101 (2): 209-14.  

Wnt/beta-catenin signaling: components, mechanisms, and diseases., MacDonald BT, Tamai K, He X., Dev Cell. July 1, 2009; 17 (1): 9-26.          

Mutational analysis of Norrin-Frizzled4 recognition., Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J., J Biol Chem. February 9, 2007; 282 (6): 4057-68.

Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling., Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T., Dev Cell. January 1, 2007; 12 (1): 129-41.

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling., Swain RK, Katoh M, Medina A, Steinbeisser H., Cell Commun Signal. October 19, 2005; 3 12.          

Comparative genomics on Dkk1 orthologs., Katoh Y, Katoh M., Int J Oncol. July 1, 2005; 27 (1): 275-9.

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy., Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dubé MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME., Nat Genet. October 1, 2002; 32 (2): 326-30.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.                

Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway., Terasaki H, Saitoh T, Shiokawa K, Katoh M., Int J Mol Med. February 1, 2002; 9 (2): 107-12.

FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway., Sagara N, Kirikoshi H, Terasaki H, Yasuhiko Y, Toda G, Shiokawa K, Katoh M., Biochem Biophys Res Commun. April 6, 2001; 282 (3): 750-6.

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling., Wu W, Glinka A, Delius H, Niehrs C., Curr Biol. December 1, 2000; 10 (24): 1611-4.        

The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling., Umbhauer M, Djiane A, Goisset C, Penzo-Méndez A, Riou JF, Boucaut JC, Shi DL., EMBO J. September 15, 2000; 19 (18): 4944-54.

Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm., Shi DL, Boucaut JC., Mech Dev. June 1, 2000; 94 (1-2): 243-5.  

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