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Summary Expression Phenotypes Gene Literature (37) GO Terms (0) Nucleotides (641) Proteins (62) Interactants (268) Wiki
XB-GENEPAGE-479633

Papers associated with slc5a8



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Novel gene expression domains reveal early patterning of the Xenopus endoderm., Costa RM, Mason J, Lee M, Amaya E, Zorn AM., Gene Expr Patterns. August 1, 2003; 3 (4): 509-19.            

Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids., Miyauchi S, Gopal E, Fei YJ, Ganapathy V., J Biol Chem. April 2, 2004; 279 (14): 13293-6.

The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter., Coady MJ, Chang MH, Charron FM, Plata C, Wallendorff B, Sah JF, Markowitz SD, Romero MF, Lapointe JY., J Physiol. June 15, 2004; 557 (Pt 3): 719-31.

Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate., Gopal E, Fei YJ, Sugawara M, Miyauchi S, Zhuang L, Martin P, Smith SB, Prasad PD, Ganapathy V., J Biol Chem. October 22, 2004; 279 (43): 44522-32.

Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family., Gopal E, Fei YJ, Miyauchi S, Zhuang L, Prasad PD, Ganapathy V., Biochem J. May 15, 2005; 388 (Pt 1): 309-16.

Subdividing the embryo: a role for Notch signaling during germ layer patterning in Xenopus laevis., Contakos SP, Gaydos CM, Pfeil EC, McLaughlin KA., Dev Biol. December 1, 2005; 288 (1): 294-307.          

Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)., Srinivas SR, Gopal E, Zhuang L, Itagaki S, Martin PM, Fei YJ, Ganapathy V, Prasad PD., Biochem J. December 15, 2005; 392 (Pt 3): 655-64.

Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT., Paroder V, Spencer SR, Paroder M, Arango D, Schwartz S, Mariadason JM, Augenlicht LH, Eskandari S, Carrasco N., Proc Natl Acad Sci U S A. May 9, 2006; 103 (19): 7270-5.

Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8)., Itagaki S, Gopal E, Zhuang L, Fei YJ, Miyauchi S, Prasad PD, Ganapathy V., Pharm Res. June 1, 2006; 23 (6): 1209-16.

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain., Martin PM, Gopal E, Ananth S, Zhuang L, Itagaki S, Prasad BM, Smith SB, Prasad PD, Ganapathy V., J Neurochem. July 1, 2006; 98 (1): 279-88.

FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development., Urban AE, Zhou X, Zhou X, Ungos JM, Raible DW, Altmann CR, Vize PD., Dev Biol. September 1, 2006; 297 (1): 103-17.                    

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract., Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, Ganapathy V., Pharm Res. March 1, 2007; 24 (3): 575-84.

Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8)., Plata C, Sussman CR, Sindic A, Liang JO, Mount DB, Josephs ZM, Chang MH, Romero MF., J Biol Chem. April 20, 2007; 282 (16): 11996-2009.

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney., Gopal E, Umapathy NS, Martin PM, Ananth S, Gnana-Prakasam JP, Becker H, Wagner CA, Ganapathy V, Prasad PD., Biochim Biophys Acta. November 1, 2007; 1768 (11): 2690-7.

Organization of the pronephric kidney revealed by large-scale gene expression mapping., Raciti D, Reggiani L, Geffers L, Jiang Q, Bacchion F, Subrizi AE, Clements D, Tindal C, Davidson DR, Kaissling B, Brändli AW., Genome Biol. January 1, 2008; 9 (5): R84.                                                                        

Vertebrate CASTOR is required for differentiation of cardiac precursor cells at the ventral midline., Christine KS, Conlon FL., Dev Cell. April 1, 2008; 14 (4): 616-23.                                

Overlapping functions of Cdx1, Cdx2, and Cdx4 in the development of the amphibian Xenopus tropicalis., Faas L, Isaacs HV., Dev Dyn. April 1, 2009; 238 (4): 835-52.                                

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate., Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, Ganapathy V., Cancer. October 15, 2009; 115 (20): 4655-66.

Anionic leak currents through the Na+/monocarboxylate cotransporter SMCT1., Coady MJ, Wallendorff B, Bourgeois F, Lapointe JY., Am J Physiol Cell Physiol. January 1, 2010; 298 (1): C124-31.

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon., Ananth S, Zhuang L, Gopal E, Itagaki S, Ellappan B, Smith SB, Ganapathy V, Martin P., Biochem Biophys Res Commun. March 26, 2010; 394 (1): 75-80.

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter., Miyauchi S, Gopal E, Babu E, Srinivas SR, Kubo Y, Umapathy NS, Thakkar SV, Ganapathy V, Prasad PD., Biochim Biophys Acta. June 1, 2010; 1798 (6): 1164-71.

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells., Babu E, Ananth S, Veeranan-Karmegam R, Coothankandaswamy V, Smith SB, Boettger T, Ganapathy V, Martin PM., Invest Ophthalmol Vis Sci. July 29, 2011; 52 (8): 5749-57.

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate., Babu E, Ramachandran S, CoothanKandaswamy V, Elangovan S, Prasad PD, Ganapathy V, Thangaraju M., Oncogene. September 22, 2011; 30 (38): 4026-37.            

Transducing bioelectric signals into epigenetic pathways during tadpole tail regeneration., Tseng AS, Levin M., Anat Rec (Hoboken). October 1, 2012; 295 (10): 1541-51.

Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo., Lobikin M, Chernet B, Lobo D, Levin M., Phys Biol. December 1, 2012; 9 (6): 065002.

Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate., Lu Y, Nakanishi T, Tamai I., Drug Metab Pharmacokinet. January 1, 2013; 28 (2): 153-8.

Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model., Chernet BT, Levin M., Dis Model Mech. May 1, 2013; 6 (3): 595-607.                  

Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range., Chernet BT, Levin M., Oncotarget. May 30, 2014; 5 (10): 3287-306.              

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria., Chino Y, Samukawa Y, Sakai S, Nakai Y, Yamaguchi J, Nakanishi T, Tamai I., Biopharm Drug Dispos. October 1, 2014; 35 (7): 391-404.                

Insulin and SGK1 reduce the function of Na+/monocarboxylate transporter 1 (SMCT1/SLC5A8)., López-Barradas A, González-Cid T, Vázquez N, Gavi-Maza M, Reyes-Camacho A, Velázquez-Villegas LA, Ramírez V, Zandi-Nejad K, Mount DB, Torres N, Tovar AR, Romero MF, Gamba G, Plata C., Am J Physiol Cell Physiol. November 1, 2016; 311 (5): C720-C734.

Uricosuric targets of tranilast., Mandal AK, Mercado A, Foster A, Zandi-Nejad K, Mount DB., Pharmacol Res Perspect. February 6, 2017; 5 (2): e00291.                    

Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8)., Sugio K, Inoda D, Masuda M, Azumaya I, Sasaki S, Shimono K, Ganapathy V, Miyauchi S., Drug Metab Pharmacokinet. February 1, 2019; 34 (1): 95-103.

Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters., Thiesen L, Frølund B, Wellendorph P., J Neurochem. April 1, 2019; 149 (2): 195-210.

Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells., Ogura J, Sato T, Higuchi K, Bhutia YD, Babu E, Masuda M, Miyauchi S, Rueda R, Pereira SL, Ganapathy V., Pharm Res. April 17, 2019; 36 (6): 84.

Genetic and Physiological Effects of Insulin on Human Urate Homeostasis., Mandal AK, Leask MP, Estiverne C, Choi HK, Merriman TR, Mount DB., Front Physiol. January 1, 2021; 12 713710.              

Thyroid Hormone Receptor Is Essential for Larval Epithelial Apoptosis and Adult Epithelial Stem Cell Development but Not Adult Intestinal Morphogenesis during Xenopus tropicalis Metamorphosis., Shibata Y, Tanizaki Y, Zhang H, Lee H, Dasso M, Shi YB, Shi YB., Cells. March 3, 2021; 10 (3):                             

Transmembrane protein 150b attenuates BMP signaling in the Xenopus organizer., Keum BR, Yeo I, Koo Y, Han W, Choi SC, Kim GH, Han JK., J Cell Physiol. August 1, 2023; 238 (8): 1850-1866.                        

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