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Summary Expression Phenotypes Gene Literature (83) GO Terms (3) Nucleotides (140) Proteins (46) Interactants (335) Wiki
XB-GENEPAGE-480034

Papers associated with slc7a5



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A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX., Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, Valera S, Barkas T, Ballivet M., Neuron. December 1, 1990; 5 (6): 847-56.

Gamma-D-glutamylaminomethyl sulfonic acid (GAMS) distinguishes kainic acid- from AMPA-induced responses in Xenopus oocytes expressing chick brain glutamate receptors., Zhou N, Hammerland LG, Parks TN., Neuropharmacology. August 1, 1993; 32 (8): 767-75.

Early expression of a novel radial glia antigen in the chick embryo., Prada FA, Dorado ME, Quesada A, Prada C, Schwarz U, de la Rosa EJ., Glia. December 1, 1995; 15 (4): 389-400.

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol., Ilyin VI, Whittemore ER, Guastella J, Weber E, Woodward RM., Mol Pharmacol. December 1, 1996; 50 (6): 1541-50.

Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia., Spindler B, Mastroberardino L, Custer M, Verrey F., Pflugers Arch. July 1, 1997; 434 (3): 323-31.

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)., Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H., J Biol Chem. September 11, 1998; 273 (37): 23629-32.

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family., Mastroberardino L, Spindler B, Pfeiffer R, Skelly PJ, Loffing J, Shoemaker CB, Verrey F., Nature. September 17, 1998; 395 (6699): 288-91.

Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond., Pfeiffer R, Spindler B, Loffing J, Skelly PJ, Shoemaker CB, Verrey F., FEBS Lett. November 13, 1998; 439 (1-2): 157-62.

Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family., Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F., EMBO J. January 4, 1999; 18 (1): 49-57.

4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer., Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, Matsuoka S, Noma A, Iwai K, Minato N., J Biol Chem. January 29, 1999; 274 (5): 3009-16.

Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene., Torrents D, Mykkänen J, Pineda M, Feliubadaló L, Estévez R, de Cid R, Sanjurjo P, Zorzano A, Nunes V, Huoponen K, Reinikainen A, Simell O, Savontaus ML, Aula P, Palacín M., Nat Genet. March 1, 1999; 21 (3): 293-6.

Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity., Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H, Kanai Y., J Biol Chem. July 9, 1999; 274 (28): 19745-51.

Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids., Pineda M, Fernández E, Torrents D, Estévez R, López C, Camps M, Lloberas J, Zorzano A, Palacín M., J Biol Chem. July 9, 1999; 274 (28): 19738-44.

A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis., Barbieri AM, Lupo G, Bulfone A, Andreazzoli M, Mariani M, Fougerousse F, Consalez GG, Borsani G, Beckmann JS, Barsacchi G, Ballabio A, Banfi S., Proc Natl Acad Sci U S A. September 14, 1999; 96 (19): 10729-34.            

[Amino acid transporter molecule as a drug target]., Endou H, Kanai Y., Nihon Yakurigaku Zasshi. October 1, 1999; 114 Suppl 1 11P-16P.

Cloning and expression of a b(0,+)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria., Rajan DP, Kekuda R, Huang W, Wang H, Devoe LD, Leibach FH, Prasad PD, Ganapathy V., J Biol Chem. October 8, 1999; 274 (41): 29005-10.

Selective expression of the large neutral amino acid transporter at the blood-brain barrier., Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM., Proc Natl Acad Sci U S A. October 12, 1999; 96 (21): 12079-84.

SPRM1lc, a heterodimeric amino acid permease light chain of the human parasitic platyhelminth, Schistosoma mansoni., Skelly PJ, Pfeiffer R, Verrey F, Shoemaker CB., Parasitology. December 1, 1999; 119 ( Pt 6) 569-76.

SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family., Bassi MT, Sperandeo MP, Incerti B, Bulfone A, Pepe A, Surace EM, Gattuso C, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Andria G, Ballabio A, Borsani G, Sebastio G., Genomics. December 1, 1999; 62 (2): 297-303.

LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine., Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kühn LC., J Biol Chem. December 3, 1999; 274 (49): 34948-54.

The heterodimeric amino acid transporter 4F2hc/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine/threonine kinase sgk-1., Wagner CA, Bröer A, Albers A, Gamper N, Lang F, Bröer S., J Physiol. July 1, 2000; 526 Pt 1 35-46.

Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains., Bröer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F, Bröer S., Biochem J. May 1, 2001; 355 (Pt 3): 725-31.

Thyroid hormone transport by the heterodimeric human system L amino acid transporter., Friesema EC, Docter R, Moerings EP, Verrey F, Krenning EP, Hennemann G, Visser TJ., Endocrinology. October 1, 2001; 142 (10): 4339-48.

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines., Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H., Biochim Biophys Acta. October 1, 2001; 1514 (2): 291-302.

Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L., Basora N, Nomura H, Berger UV, Stayner C, Guo L, Shen X, Zhou J., J Am Soc Nephrol. February 1, 2002; 13 (2): 293-301.

Activation of system L heterodimeric amino acid exchangers by intracellular substrates., Meier C, Ristic Z, Klauser S, Verrey F., EMBO J. February 15, 2002; 21 (4): 580-9.

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition., Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H., Mol Pharmacol. April 1, 2002; 61 (4): 729-37.

Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells., Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H., Biochim Biophys Acta. September 20, 2002; 1565 (1): 112-21.

Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2., Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N., Biochem J. October 1, 2002; 367 (Pt 1): 239-46.

Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch., Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG., EMBO J. November 15, 2002; 21 (22): 6195-204.

Asymmetry of glutamine transporters in cultured neural cells., Heckel T, Bröer A, Wiesinger H, Lang F, Bröer S., Neurochem Int. January 1, 2003; 43 (4-5): 289-98.

Characterization of 3-[125I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1., Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H., Nucl Med Biol. January 1, 2003; 30 (1): 31-7.

Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234., Boado RJ, Li JY, Pardridge WM., J Neurochem. March 1, 2003; 84 (6): 1322-31.

Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation., Tay J, Hodgman R, Sarkissian M, Richter JD., Genes Dev. June 15, 2003; 17 (12): 1457-62.

Identification, functional characterization and expression of a LAT type amino acid transporter from the mosquito Aedes aegypti., Jin X, Aimanova K, Ross LS, Gill SS., Insect Biochem Mol Biol. August 1, 2003; 33 (8): 815-27.

Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters., Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H., J Biol Chem. October 31, 2003; 278 (44): 43838-45.

Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development., Latinkic BV, Cooper B, Smith S, Kotecha S, Towers N, Sparrow D, Mohun TJ., Development. February 1, 2004; 131 (3): 669-79.                    

SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes., Zecevic M, Heitzmann D, Camargo SM, Verrey F., Pflugers Arch. April 1, 2004; 448 (1): 29-35.

Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality., Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP., Mol Cell Biol. August 1, 2004; 24 (16): 7102-12.

Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome., Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW., Gene Expr Patterns. October 1, 2004; 4 (6): 611-9.            

Identification of LAT4, a novel amino acid transporter with system L activity., Bodoy S, Martín L, Zorzano A, Palacín M, Estévez R, Bertran J., J Biol Chem. March 25, 2005; 280 (12): 12002-11.

Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols., Li S, Whorton AR., J Biol Chem. May 20, 2005; 280 (20): 20102-10.

Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association., Franca R, Veljkovic E, Walter S, Wagner CA, Verrey F., Biochem J. June 1, 2005; 388 (Pt 2): 435-43.

Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1., Boado RJ, Li JY, Chu C, Ogoshi F, Wise P, Pardridge WM., Biochim Biophys Acta. September 15, 2005; 1715 (2): 104-10.

Wnt5 signaling in vertebrate pancreas development., Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC., BMC Biol. October 24, 2005; 3 23.                    

Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells., Kim SG, Kim HH, Kim HK, Kim CH, Chun HS, Kanai Y, Endou H, Kim do K., Anticancer Res. January 1, 2006; 26 (3A): 1989-96.

Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development., Auden A, Caddy J, Wilanowski T, Ting SB, Cunningham JM, Jane SM., Gene Expr Patterns. October 1, 2006; 6 (8): 964-70.          

Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells., Li S, Whorton AR., Am J Physiol Cell Physiol. April 1, 2007; 292 (4): C1263-71.

Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger., Ramadan T, Camargo SM, Herzog B, Bordin M, Pos KM, Verrey F., Pflugers Arch. June 1, 2007; 454 (3): 507-16.

Neural MMP-28 expression precedes myelination during development and peripheral nerve repair., Werner SR, Mescher AL, Neff AW, King MW, King MW, Chaturvedi S, Duffin KL, Harty MW, Smith RC., Dev Dyn. October 1, 2007; 236 (10): 2852-64.              

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