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Summary Expression Phenotypes Gene Literature (732) GO Terms (8) Nucleotides (645) Proteins (64) Interactants (2315) Wiki
XB--480637

Papers associated with chrd.1 (and Disease Ontology)



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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling., Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E., Nat Commun. October 5, 2023; 14 (1): 6173.                                

Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion., Edri T, Cohen D, Shabtai Y, Fainsod A., Front Cell Dev Biol. January 1, 2023; 11 1282273.                    

Lysosomes are required for early dorsal signaling in the Xenopus embryo., Tejeda-Muñoz N, De Robertis EM., Proc Natl Acad Sci U S A. April 26, 2022; 119 (17): e2201008119.                          

Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression., Kumar S, Kumar S, Kumar V, Li W, Kim J., Int J Mol Sci. March 1, 2022; 23 (5):         

Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly., Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A., Front Cell Dev Biol. January 1, 2022; 10 844619.                        

A convergent molecular network underlying autism and congenital heart disease., Rosenthal SB, Willsey HR, Xu Y, Xu Y, Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK, Chi NC, Willsey AJ, Fisch KM, Ideker T., Cell Syst. November 17, 2021; 12 (11): 1094-1107.e6.            

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis., Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN., Dev Cell. April 19, 2021; 56 (8): 1118-1130.e6.                                  

Geoffroea decorticans fruit extracts inhibit the wnt/β-catenin pathway, a therapeutic target in cancer., Somaini GC, Aybar MJ, Vera NR, Tríbulo C., Biochem Biophys Res Commun. March 26, 2021; 546 118-123.          

Establishing embryonic territories in the context of Wnt signaling., Velloso I, Maia LA, Amado NG, Reis AH, He X, Abreu JG., Int J Dev Biol. January 1, 2021; 65 (4-5-6): 227-233.      

R-spondins are BMP receptor antagonists in Xenopus early embryonic development., Lee H, Lee H, Seidl C, Sun R, Glinka A, Niehrs C., Nat Commun. November 4, 2020; 11 (1): 5570.                                            

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis., Chen M, Amado N, Tan J, Reis A, Ge M, Abreu JG, He X., Elife. September 14, 2020; 9                                                                                           

Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects., Marquez J, Criscione J, Charney RM, Prasad MS, Hwang WY, Mis EK, García-Castro MI, Khokha MK., J Clin Invest. February 3, 2020; 130 (2): 813-826.                                

Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor., Jalvy S, Veschambre P, Fédou S, Rezvani HR, Thézé N, Thiébaud P., Dev Biol. March 15, 2019; 447 (2): 200-213.                                  

Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis., Harata A, Hirakawa M, Sakuma T, Yamamoto T, Hashimoto C., Dev Growth Differ. February 1, 2019; 61 (2): 186-197.                                

Quantitative Phenotyping of Xenopus Embryonic Heart Pathophysiology Using Hemoglobin Contrast Subtraction Angiography to Screen Human Cardiomyopathies., Deniz E, Jonas S, Khokha MK, Choma MA., Front Physiol. January 1, 2019; 10 1197.      

Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction., Shi Y, Shi Y, Li J, Chen C, Xia Y, Li Y, Zhang P, Xu Y, Xu Y, Li T, Zhou W, Song W., Front Mol Neurosci. February 7, 2018; 11 9.          

Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity., Shabtai Y, Bendelac L, Jubran H, Hirschberg J, Fainsod A., Sci Rep. January 10, 2018; 8 (1): 347.                  

CRISPR/Cas9 F0 Screening of Congenital Heart Disease Genes in Xenopus tropicalis., Deniz E, Mis EK, Lane M, Khokha MK., Methods Mol Biol. January 1, 2018; 1865 163-174.

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.                                

An interspecies heart-to-heart: Using Xenopus to uncover the genetic basis of congenital heart disease., Garfinkel AM, Khokha MK., Curr Pathobiol Rep. June 1, 2017; 5 (2): 187-196.

NF2/Merlin is required for the axial pattern formation in the Xenopus laevis embryo., Zhu X, Min Z, Tan R, Tao Q, Tao Q., Mech Dev. November 1, 2015; 138 Pt 3 305-12.                

Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model., Pfirrmann T, Emmerich D, Ruokonen P, Quandt D, Buchen R, Fischer-Zirnsak B, Hecht J, Krawitz P, Meyer P, Klopocki E, Stricker S, Lausch E, Seliger B, Hollemann T, Reinhard T, Auw-Haedrich C, Zabel B, Hoffmann K, Villavicencio-Lorini P., Hum Mol Genet. June 1, 2015; 24 (11): 3119-32.

Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway., Amado NG, Predes D, Fonseca BF, Cerqueira DM, Reis AH, Dudenhoeffer AC, Borges HL, Mendes FA, Abreu JG., J Biol Chem. December 19, 2014; 289 (51): 35456-67.                  

The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling., Iwasaki Y, Thomsen GH., Development. October 1, 2014; 141 (19): 3740-51.                                          

The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling., Wang F, Hu W, Xian J, Ohnuma S, Brenton JD., Dev Biol. July 1, 2013; 379 (1): 16-27.                            

Maternal xNorrin, a canonical Wnt signaling agonist and TGF-β antagonist, controls early neuroectoderm specification in Xenopus., Xu S, Cheng F, Liang J, Wu W, Zhang J., PLoS Biol. January 1, 2012; 10 (3): e1001286.                                    

CHD7 cooperates with PBAF to control multipotent neural crest formation., Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J., Nature. February 18, 2010; 463 (7283): 958-62.      

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction., Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu TC, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN., Nat Cell Biol. January 1, 2009; 11 (1): 46-55.            

Early molecular effects of ethanol during vertebrate embryogenesis., Yelin R, Kot H, Yelin D, Fainsod A., Differentiation. June 1, 2007; 75 (5): 393-403.                    

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase., Koide T, Hayata T, Cho KW., Development. June 1, 2006; 133 (12): 2395-405.                

AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development., Lim JH, Booker AB, Luo T, Williams T, Furuta Y, Lagutin O, Oliver G, Sargent TD, Fallon JR., Hum Mol Genet. July 15, 2005; 14 (14): 2027-34.    

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos., Tao Q, Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J., Cell. March 25, 2005; 120 (6): 857-71.            

Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels., Yelin R, Schyr RB, Kot H, Zins S, Frumkin A, Pillemer G, Fainsod A., Dev Biol. March 1, 2005; 279 (1): 193-204.                  

Expression cloning of Xenopus Os4, an evolutionarily conserved gene, which induces mesoderm and dorsal axis., Zohn IE, Brivanlou AH., Dev Biol. November 1, 2001; 239 (1): 118-31.                    

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