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Summary Expression Phenotypes Gene Literature (120) GO Terms (7) Nucleotides (156) Proteins (52) Interactants (635) Wiki
XB-GENEPAGE-481819

Papers associated with lrp6



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referenced by:

LDL-receptor-related proteins in Wnt signal transduction., Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X., Nature. September 28, 2000; 407 (6803): 530-5.

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins., Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C., Nature. May 17, 2001; 411 (6835): 321-5.

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6., Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X., Curr Biol. June 26, 2001; 11 (12): 951-61.

Cloning and expression of Xenopus Lrp5 and Lrp6 genes., Houston DW, Wylie C., Mech Dev. September 1, 2002; 117 (1-2): 337-42.      

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins., Brott BK, Sokol SY., Mol Cell Biol. September 1, 2002; 22 (17): 6100-10.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling., Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO., J Biol Chem. September 20, 2002; 277 (38): 34727-35.                

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning., Davidson G, Mao B, del Barco Barrantes I, Niehrs C., Development. December 1, 2002; 129 (24): 5587-96.        

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling., Mao B, Niehrs C., Gene. January 2, 2003; 302 (1-2): 179-83.        

Wise, a context-dependent activator and inhibitor of Wnt signalling., Itasaki N, Jones CM, Mercurio S, Rowe A, Domingos PM, Smith JC, Krumlauf R., Development. September 1, 2003; 130 (18): 4295-305.                

Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex., Mercurio S, Latinkic B, Itasaki N, Krumlauf R, Smith JC., Development. May 1, 2004; 131 (9): 2137-47.                    

Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF., Yamamoto A, Nagano T, Takehara S, Hibi M, Aizawa S., Cell. January 28, 2005; 120 (2): 223-35.                      

Comparative genomics on Dkk1 orthologs., Katoh Y, Katoh M., Int J Oncol. July 1, 2005; 27 (1): 275-9.

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor., Semënov M, Tamai K, He X., J Biol Chem. July 22, 2005; 280 (29): 26770-5.

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling., Swain RK, Katoh M, Medina A, Steinbeisser H., Cell Commun Signal. October 19, 2005; 3 12.          

Early steps in neural crest specification., Barembaum M, Bronner-Fraser M., Semin Cell Dev Biol. December 1, 2005; 16 (6): 642-6.      

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation., Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X., Nature. December 8, 2005; 438 (7069): 873-7.

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction., Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C., Nature. December 8, 2005; 438 (7069): 867-72.

The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition., Cruciat CM, Hassler C, Niehrs C., J Biol Chem. May 5, 2006; 281 (18): 12986-93.                        

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity., Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R., J Bone Miner Res. November 1, 2006; 21 (11): 1738-49.              

Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos., Nagano T, Takehara S, Takahashi M, Aizawa S, Yamamoto A., Development. December 1, 2006; 133 (23): 4643-54.                  

Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin., Kofron M, Birsoy B, Houston D, Tao Q, Tao Q, Wylie C, Heasman J., Development. February 1, 2007; 134 (3): 503-13.      

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo., Bryja V, Gradl D, Schambony A, Arenas E, Schulte G., Proc Natl Acad Sci U S A. April 17, 2007; 104 (16): 6690-5.  

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling., Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X., J Biol Chem. May 25, 2007; 282 (21): 15903-11.  

Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings., Furushima K, Yamamoto A, Nagano T, Shibata M, Miyachi H, Abe T, Ohshima N, Kiyonari H, Aizawa S., Dev Biol. June 15, 2007; 306 (2): 480-92.  

Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6., Guidato S, Itasaki N., Dev Biol. October 15, 2007; 310 (2): 250-63.                

Lrp6 is required for convergent extension during Xenopus gastrulation., Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E., Development. November 1, 2007; 134 (22): 4095-106.

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal., Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM., Cell. November 30, 2007; 131 (5): 980-93.      

Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling., Hassler C, Cruciat CM, Huang YL, Kuriyama S, Mayor R, Niehrs C., Development. December 1, 2007; 134 (23): 4255-63.      

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions., Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X., Development. January 1, 2008; 135 (2): 367-75.

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling., Piao S, Lee SH, Kim H, Yum S, Stamos JL, Xu Y, Xu Y, Lee SJ, Lee J, Lee J, Oh S, Han JK, Park BJ, Weis WI, Ha NC., PLoS One. January 1, 2008; 3 (12): e4046.          

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen., Cselenyi CS, Lee E, Lee E., Sci Signal. February 26, 2008; 1 (8): pe10.

Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway., Hendriksen J, Jansen M, Brown CM, van der Velde H, van Ham M, Galjart N, Offerhaus GJ, Fagotto F, Fornerod M., J Cell Sci. June 1, 2008; 121 (11): 1793-802.

Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6., MacDonald BT, Yokota C, Tamai K, Zeng X, He X., J Biol Chem. June 6, 2008; 283 (23): 16115-23.

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin., Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E, Lee E., Proc Natl Acad Sci U S A. June 10, 2008; 105 (23): 8032-7.        

Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling., Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A., Dev Cell. July 1, 2008; 15 (1): 37-48.

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis., Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I., Nature. July 17, 2008; 454 (7202): 345-9.                        

Extracellular regulation of developmental cell signaling by XtSulf1., Freeman SD, Moore WM, Guiral EC, Holme AD, Turnbull JE, Pownall ME., Dev Biol. August 15, 2008; 320 (2): 436-45.            

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation., Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D., Science. September 5, 2008; 321 (5894): 1350-3.

Parathyroid hormone signaling through low-density lipoprotein-related protein 6., Wan M, Yang C, Li J, Wu X, Yuan H, Ma H, He X, Nie S, Chang C, Cao X., Genes Dev. November 1, 2008; 22 (21): 2968-79.  

Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6., Wu G, Huang H, Garcia Abreu J, He X., PLoS One. January 1, 2009; 4 (3): e4926.              

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo., Bryja V, Andersson ER, Schambony A, Esner M, Bryjová L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E., Mol Biol Cell. February 1, 2009; 20 (3): 924-36.        

Wnt/beta-catenin signaling: components, mechanisms, and diseases., MacDonald BT, Tamai K, He X., Dev Cell. July 1, 2009; 17 (1): 9-26.          

Cell cycle control of wnt receptor activation., Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C., Dev Cell. December 1, 2009; 17 (6): 788-99.    

Macrophage Wnt7b is critical for kidney repair and regeneration., Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS., Proc Natl Acad Sci U S A. March 2, 2010; 107 (9): 4194-9.      

Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family., Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX., Proc Natl Acad Sci U S A. April 13, 2010; 107 (15): 6900-5.

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity., Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E., Sci Signal. May 11, 2010; 3 (121): ra37.

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members., Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD., J Cell Sci. December 15, 2010; 123 (Pt 24): 4351-65.

Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling., Day RC, Beck CW., BMC Dev Biol. January 26, 2011; 11 54.                                                

Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2., Hikasa H, Sokol SY., J Biol Chem. April 8, 2011; 286 (14): 12093-100.

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development., Paulsen M, Legewie S, Eils R, Karaulanov E, Niehrs C., Proc Natl Acad Sci U S A. June 21, 2011; 108 (25): 10202-7.      

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