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Summary Expression Phenotypes Gene Literature (107) GO Terms (42) Nucleotides (137) Proteins (31) Interactants (785) Wiki
XB-GENEPAGE-481819

Papers associated with lrp6

Search for lrp6 morpholinos using Textpresso

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17 paper(s) referencing morpholinos

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The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation., Niehrs C., Dev Biol. November 21, 2021; 482 1-6.


Signaling Control of Mucociliary Epithelia: Stem Cells, Cell Fates, and the Plasticity of Cell Identity in Development and Disease., Walentek P., Cells Tissues Organs. April 26, 2021; 1-18.


Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis., Colozza G., MicroPubl Biol. January 5, 2021; 2021   


Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development., Krishnamurthy VV, Hwang H, Fu J, Yang J, Zhang K., J Mol Biol. January 1, 2021; 433 (18): 167050.


The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C., Elife. January 1, 2020; 9                                                                                               


eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G., J Biol Chem. January 1, 2020; 295 (26): 8759-8774.          


TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis., Chen M, Amado N, Tan J, Reis A, Ge M, Abreu JG, He X., Elife. January 1, 2020; 9                                                                                           


Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains., Kim J, Han W, Park T, Kim EJ, Bang I, Lee HS, Jeong Y, Roh K, Kim J, Kim JS, Kang C, Seok C, Han JK, Choi HJ., Nat Commun. January 1, 2020; 11 (1): 5357.            


R-spondins are BMP receptor antagonists in Xenopus early embryonic development., Lee H, Seidl C, Sun R, Glinka A, Niehrs C., Nat Commun. January 1, 2020; 11 (1): 5570.                                            


Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway., Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Muñoz N, Albrecht LV, Sosa EA, Wohlschlegel JA, De Robertis EM., Sci Rep. January 1, 2020; 10 (1): 21555.            


Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway., Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E., Mech Dev. January 1, 2019; 156 20-31.                              


Crystal structure of a mammalian Wnt-frizzled complex., Hirai H, Matoba K, Mihara E, Arimori T, Takagi J., Nat Struct Mol Biol. January 1, 2019; 26 (5): 372-379.


PTK7 proteolytic fragment proteins function during early Xenopus development., Lichtig H, Cohen Y, Bin-Nun N, Golubkov V, Frank D., Dev Biol. January 1, 2019; 453 (1): 48-55.        


PAWS1 controls Wnt signalling through association with casein kinase 1α., Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP., EMBO Rep. January 1, 2018; 19 (4):                             


Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1., Lee H, Cheong SM, Han W, Koo Y, Jo SB, Cho GS, Yang JS, Kim S, Han JK., Development. January 1, 2018; 145 (7):               


Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner., Devotta A, Hong CS, Saint-Jeannet JP., Elife. January 1, 2018; 7                             


Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis., Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM., Proc Natl Acad Sci U S A. January 1, 2018; 115 (39): E9135-E9144.                    


Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates., Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q, Tao Q, Meng A., Science. January 1, 2018; 362 (6417):


Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling., Han W, Lee H, Han JK., Sci Rep. January 1, 2017; 7 42590.                        


The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning., Rauschenberger V, Bernkopf DB, Krenn S, Jalal K, Heller J, Behrens J, Gentzel M, Schambony A., Development. January 1, 2017; 144 (12): 2234-2247.                                      


Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways., Qi J, Lee HJ, Saquet A, Cheng XN, Shao M, Zheng JJ, Shi DL., J Biol Chem. January 1, 2017; 292 (14): 5898-5908.


Apolipoprotein C-I mediates Wnt/Ctnnb1 signaling during neural border formation and is required for neural crest development., Yokota C, Åstrand C, Takahashi S, Hagey DW, Stenman JM., Int J Dev Biol. January 1, 2017; 61 (6-7): 415-425.                      


Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover., Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C., Dev Cell. January 1, 2017; 43 (1): 71-82.e6.                                


A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway., Salašová A, Yokota C, Potěšil D, Zdráhal Z, Bryja V, Arenas E., Mol Neurodegener. January 1, 2017; 12 (1): 54.  


Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus., Mii Y, Yamamoto T, Takada R, Mizumoto S, Matsuyama M, Yamada S, Takada S, Taira M., Nat Commun. January 1, 2017; 8 (1): 1973.                                                  


Aberrant regulation of Wnt signaling in hepatocellular carcinoma., Liu LJ, Xie SX, Chen YT, Xue JL, Zhang CJ, Zhu F., World J Gastroenterol. September 7, 2016; 22 (33): 7486-99.      


Capsaicin inhibits the Wnt/β-catenin signaling pathway by down-regulating PP2A., Park DS, Yoon GH, Lee HS, Choi SC., Biochem Biophys Res Commun. January 1, 2016; 478 (1): 455-461.              


Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation., Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J, Jho EH., Cell Death Differ. January 1, 2016; 23 (10): 1638-47.


A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators., Freeman J, Smith D, Latinkic B, Ewan K, Samuel L, Zollo M, Marino N, Tyas L, Jones N, Dale TC., Mol Cancer. December 8, 2015; 14 206.              


Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism., Haramoto Y, Takahashi S, Oshima T, Onuma Y, Ito Y, Asashima M., Sci Rep. September 21, 2015; 5 11603.                                  


Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development., Sokol SY., Semin Cell Dev Biol. June 1, 2015; 42 78-85.      


Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis., Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C., Proc Natl Acad Sci U S A. May 5, 2015; 112 (18): 5732-7.


CD44 functions in Wnt signaling by regulating LRP6 localization and activation., Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V., Cell Death Differ. April 1, 2015; 22 (4): 677-89.


Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling., Fellgett SW, Maguire RJ, Pownall ME., J Cell Sci. April 1, 2015; 128 (7): 1408-21.                        


Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation., Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X., Dev Cell. March 23, 2015; 32 (6): 719-30.                                  


A Molecular atlas of Xenopus respiratory system development., Rankin SA, Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Vleminckx K, Wert SE, Zorn AM., Dev Dyn. January 1, 2015; 244 (1): 69-85.                    


Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway., Amado NG, Predes D, Fonseca BF, Cerqueira DM, Reis AH, Dudenhoeffer AC, Borges HL, Mendes FA, Abreu JG., J Biol Chem. December 19, 2014; 289 (51): 35456-67.                  


Getting to know your neighbor: cell polarization in early embryos., Nance J., J Cell Biol. September 29, 2014; 206 (7): 823-32.          


In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos., Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S., J Cell Sci. September 15, 2014; 127 (Pt 18): 3970-82.                  


Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling., Sheng R, Kim H, Lee H, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK, Cho W., Nat Commun. July 15, 2014; 5 4393.              


Polarized Wnt signaling regulates ectodermal cell fate in Xenopus., Huang YL, Niehrs C., Dev Cell. April 28, 2014; 29 (2): 250-7.                  


The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          


Syndecan-4 inhibits Wnt/β-catenin signaling through regulation of low-density-lipoprotein receptor-related protein (LRP6) and R-spondin 3., Astudillo P, Carrasco H, Larraín J., Int J Biochem Cell Biol. January 1, 2014; 46 103-12.            


PTK7 modulates Wnt signaling activity via LRP6., Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D., Development. January 1, 2014; 141 (2): 410-21.              


RAB8B is required for activity and caveolar endocytosis of LRP6., Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C, Boutros M., Cell Rep. September 26, 2013; 4 (6): 1224-34.                    


Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains., Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G., Dev Cell. August 26, 2013; 26 (4): 331-45.


structural Studies of Wnts and identification of an LRP6 binding site., Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI., Structure. July 2, 2013; 21 (7): 1235-42.


The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling., Wang F, Hu W, Xian J, Ohnuma S, Brenton JD., Dev Biol. July 1, 2013; 379 (1): 16-27.                            


Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling., Park DS, Seo JH, Hong M, Choi SC., Biochem Biophys Res Commun. June 28, 2013; 436 (2): 338-43.        


Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies., Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X., Science. May 17, 2013; 340 (6134): 867-70.

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