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Summary Expression Phenotypes Gene Literature (147) GO Terms (6) Nucleotides (164) Proteins (70) Interactants (1267) Wiki
XB--482491

Papers associated with pitx2 (and Disease Ontology)



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Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease., Mishra-Gorur K, Barak T, Kaulen LD, Henegariu O, Jin SC, Aguilera SM, Yalbir E, Goles G, Nishimura S, Miyagishima D, Djenoune L, Altinok S, Rai DK, Viviano S, Prendergast A, Zerillo C, Ozcan K, Baran B, Sencar L, Goc N, Yarman Y, Ercan-Sencicek AG, Bilguvar K, Lifton RP, Moliterno J, Louvi A, Yuan S, Deniz E, Brueckner M, Gunel M., Proc Natl Acad Sci U S A. April 18, 2023; 120 (16): e2214997120.                                            

Mink1 regulates spemann organizer cell fate in the xenopus gastrula via Hmga2., Colleluori V, Khokha MK., Dev Biol. March 1, 2023; 495 42-53.                            

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates., Szenker-Ravi E, Ott T, Khatoo M, Moreau de Bellaing A, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B., Nat Genet. January 1, 2022; 54 (1): 62-72.

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease., Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS., Proc Natl Acad Sci U S A. September 28, 2021; 118 (39):                                                   

Single-minded 2 is required for left-right asymmetric stomach morphogenesis., Wyatt BH, Amin NM, Bagley K, Wcisel DJ, Dush MK, Yoder JA, Nascone-Yoder NM., Development. September 1, 2021; 148 (17):                 

Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling., Flach H, Basten T, Schreiner C, Dietmann P, Greco S, Nies L, Roßmanith N, Walter S, Kühl M, Kühl SJ., Dev Dyn. August 1, 2021; 250 (8): 1096-1112.                

Altering metabolite distribution at Xenopus cleavage stages affects left-right gene expression asymmetries., Onjiko RM, Nemes P, Moody SA., Genesis. June 1, 2021; 59 (5-6): e23418.          

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis., Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN., Dev Cell. April 19, 2021; 56 (8): 1118-1130.e6.                                  

Aquatic models of human ciliary diseases., Corkins ME, Krneta-Stankic V, Kloc M, Miller RK., Genesis. February 1, 2021; 59 (1-2): e23410.          

Nucleoporin NUP205 plays a critical role in cilia and congenital disease., Marquez J, Bhattacharya D, Lusk CP, Khokha MK., Dev Biol. January 1, 2021; 469 46-53.                        

Modeling endoderm development and disease in Xenopus., Edwards NA, Zorn AM., Curr Top Dev Biol. January 1, 2021; 145 61-90.

CFAP43 modulates ciliary beating in mouse and Xenopus., Rachev E, Schuster-Gossler K, Fuhl F, Ott T, Tveriakhina L, Beckers A, Hegermann J, Boldt K, Mai M, Kremmer E, Ueffing M, Blum M, Gossler A., Dev Biol. March 15, 2020; 459 (2): 109-125.                                                                    

WDR5 regulates left-right patterning via chromatin-dependent and -independent functions., Kulkarni SS, Khokha MK., Development. November 28, 2018; 145 (23):                 

A Conserved Role of the Unconventional Myosin 1d in Laterality Determination., Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M., Curr Biol. March 5, 2018; 28 (5): 810-816.e3.                

Candidate Heterotaxy Gene FGFR4 Is Essential for Patterning of the Left-Right Organizer in Xenopus., Sempou E, Lakhani OA, Amalraj S, Khokha MK., Front Physiol. January 1, 2018; 9 1705.              

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways., Sigg MA, Menchen T, Lee C, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF., Dev Cell. December 18, 2017; 43 (6): 744-762.e11.      

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates., Plouhinec JL, Medina-Ruiz S, Borday C, Bernard E, Vert JP, Eisen MB, Harland RM, Monsoro-Burq AH., PLoS Biol. October 19, 2017; 15 (10): e2004045.                                              

Mouth development., Chen J, Jacox LA, Saldanha F, Sive H., Wiley Interdiscip Rev Dev Biol. September 1, 2017; 6 (5):               

Id genes are essential for early heart formation., Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR., Genes Dev. July 1, 2017; 31 (13): 1325-1338.                

Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?, Gentzel M, Schambony A., Front Cell Dev Biol. May 26, 2017; 5 59.    

Leftward Flow Determines Laterality in Conjoined Twins., Tisler M, Thumberger T, Schneider I, Schweickert A, Blum M., Curr Biol. February 20, 2017; 27 (4): 543-548.                

Roles of the cilium-associated gene CCDC11 in left-right patterning and in laterality disorders in humans., Gur M, Cohen EB, Genin O, Fainsod A, Perles Z, Cinnamon Y., Int J Dev Biol. January 1, 2017; 61 (3-4-5): 267-276.          

Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia., Del Viso F, Huang F, Myers J, Chalfant M, Zhang Y, Reza N, Bewersdorf J, Lusk CP, Khokha MK., Dev Cell. September 12, 2016; 38 (5): 478-92.                        

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery., Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ, University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB., Nat Genet. June 1, 2016; 48 (6): 648-56.                              

Xenopus as a model organism for birth defects-Congenital heart disease and heterotaxy., Duncan AR, Khokha MK., Semin Cell Dev Biol. March 1, 2016; 51 73-9.    

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry., Endicott SJ, Basu B, Khokha M, Brueckner M., Development. December 1, 2015; 142 (23): 4068-79.                                  

Novel BCOR mutation in a boy with Lenz microphthalmia/oculo-facio-cardio-dental (OFCD) syndrome., Zhu X, Dai FR, Wang J, Zhang Y, Tan ZP, Zhang Y., Gene. October 15, 2015; 571 (1): 142-4.    

A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome., Tanaka K, Kato A, Angelocci C, Watanabe M, Kato Y., Dev Biol. March 1, 2014; 387 (1): 28-36.        

Embryonic exposure to propylthiouracil disrupts left-right patterning in Xenopus embryos., van Veenendaal NR, Ulmer B, Boskovski MT, Fang X, Khokha MK, Wendler CC, Blum M, Rivkees SA., FASEB J. February 1, 2013; 27 (2): 684-91.

An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis., Cast AE, Gao C, Amack JD, Ware SM., Dev Biol. April 1, 2012; 364 (1): 22-31.            

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning., Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M., Proc Natl Acad Sci U S A. February 15, 2011; 108 (7): 2915-20.                      

Lessons from the lily pad: Using Xenopus to understand heart disease., Bartlett HL, Weeks DL., Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.

Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination., Hilton EN, Manson FD, Urquhart JE, Johnston JJ, Slavotinek AM, Hedera P, Stattin EL, Nordgren A, Biesecker LG, Black GC., Hum Mol Genet. July 15, 2007; 16 (14): 1773-82.              

Molecular mechanisms of vertebrate left-right development., Ramsdell AF, Yost HJ., Trends Genet. November 1, 1998; 14 (11): 459-65.

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